Person: MUMCU, GONCA
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
MUMCU
First Name
GONCA
Name
24 results
Search Results
Now showing 1 - 10 of 24
Publication Metadata only Femoral vein wall thickness measurement: A new diagnostic tool for Behcet's disease(OXFORD UNIV PRESS, 2021) ALİBAZ ÖNER, FATMA; Alibaz-Oner, Fatma; Ergelen, Rabia; Yildiz, Yasin; Aldag, Mustafa; Yazici, Ayten; Cefle, Ayse; Koc, Ertan; Esen, Bahar Artim; Mumcu, Gonca; Ergun, Tulin; Direskeneli, HanerObjectives. Diagnosing Behcet's disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Methods.. Patients with BD (n=152), ankylosing spondylitis (n=27), systemic vasculitides (n=23), venous insufficiency (n=29), antiphospholipid syndrome (APS; n=43), deep vein thrombosis due to non-inflammatory causes (n=25) and healthy controls (n=51) were included in the study. Bilateral CFV thickness was measured with ultrasonography by a radiologist blinded to cases. Results. Bilateral CFV thickness was significantly increased in BD compared with all control groups (P < 0.001 for all). The area under the receiver operating characteristic curve for bilateral CFV thicknesses in all comparator groups was >0.95 for the cut-off value (0.5 mm). This cut-off value also performed well against all control groups with sensitivity rates >90%. The specificity rate was also >80% in all comparator groups except APS (positive predictive value: 79.2-76.5%, negative predictive value: 92-91.8% for right and left CFV, respectively). Conclusion. Increased CFV thickness is a distinctive feature of BD and is rarely present in healthy and diseased controls, except APS. Our results suggest that CFV thickness measurement with ultrasonography, a non-invasive radiological modality, can be a diagnostic tool for BD with sensitivity and the specificity rates higher than 80% for the cut-off value >= 0.5mm.Publication Metadata only The novel OMERACT Ultrasound Scoring System for salivary glands changes in patients with Sjögren's syndrome is associated with MRI and salivary flow rates(2023-11-01) MUMCU, GONCA; ÇİMŞİT, CANAN; Inanc N., Jousse-Joulin S., Abacar K., Cimşit C., Cimşit C., D'Agostino M., Naredo E., Hocevar A., Finzel S., Pineda C., et al.Objective To assess the construct validity of the novel Outcome Measures in Rheumatology (OMERACT) ultrasound (US) semiquantitative scoring system for morphological lesions in major salivary glands by comparing it with magnetic resonance imaging (MRI) and unstimulated whole salivary flow rates (U-WSFRs) in patients with primary Sjögren syndrome (pSS). Methods Nine sonographers applied the OMERACT 0-3 grayscale scoring system for parotid (PGs) and submandibular glands (SMGs) in 11 patients with pSS who also had MRIs performed. These were evaluated by 2 radiologists using a semiquantitative 0-3 scoring system for morphological lesions. The agreement between US and MRI and the association between U-WSFRs and imaging structural lesions was determined. A score ≥ 2 for both US and MRI was defined as gland pathology. Results The prevalence of US morphological lesions in 11 patients with a score ≥ 2 was 58% for PGs and 76% for SMGs, and 46% and 41% for PGs and SMGs, respectively, for MRI. The agreement between OMERACT US scores and MRI scores was 73-91% (median 82%) in the right PG and 73-91% (median 91%) in the left PG, 55-91% (median 55%) in the right SMG and 55-82% (median 55%) in the left SMG. When relations between the presence of hyposalivation and an US score ≥ 2 were examined, agreement was 91-100% (median 83%) in both PGs and 55-91% (median 67%) in both SMGs. Conclusion There is moderate to strong agreement between the OMERACT US and MRI scores for major salivary glands in patients with pSS. Similar agreement ratios were observed between the higher OMERACT US scores and presence of hyposalivation.Publication Open Access Assessment of students anxiety level and technology readiness in a simulation-based obstetrics training(2023-01-01) ÇATAR, RAMAZAN ÖZGÜR; KİTAPÇI, OKAN CEM; ŞİŞMAN KİTAPÇI, NUR; DEMİRGÖZ BAL, MELTEM; MUMCU, GONCA; Ayyıldız S., ÇANDERELİ Z. Ö., KILIÇ AKSU P., ÇATAR R. Ö., KİTAPÇI O. C., ŞİŞMAN KİTAPÇI N., KÖKSAL L., DEMİRGÖZ BAL M., MUMCU G.Aim: This study aims to evaluate the effects of simulation-based obstetrics training on students' professional development and examine students' anxiety and technology readiness. Material and Methods: The study was quasi-experimental and performed with 3rd -year students in Midwifery Department (n=60) between September 2018 and January 2019. Students attended a 14-week simulation-based delivery training. In the pre-and posttraining periods, the data were collected by the State-Trait Anxiety Inventory (STAI) and the Tendency Scale for the Use of Technology. Results: Students reported that simulation-based delivery training improved their "professional skills" (95%) and "professional internalization" (93.4%). They stated that there was a positive effect on "anxiety in the working environment" (93.3%) in posttraining. Since no significant differences were observed in scores of the Tendency Scale for the Use of Technology and STAI in pre-and post-training periods (p>0.05), it was thought that they were not potential barrier factors in the training. Conclusion: The ensuring of professional development was achieved by using simulation-based training in the study. However, technology readiness and anxiety levels were stable in pre-and post-training periodsPublication Open Access A MODERATED MEDIATION ANALYSIS FOR POOR ORAL HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BEHCET'S DISEASE(BMJ PUBLISHING GROUP, 2021-06) ALİBAZ ÖNER, FATMA; Cakir, E. N.; Yenisoy, Y.; Kapusuz, A.; Abacar, K.; Alibaz-Oner, F.; Yay, M.; Karacayli, U.; Inanc, N.; Ergun, T.; Direskeneli, H.; Mumcu, G.Publication Open Access The OMERACT Core Set of Domains for Outcome Measures in Behçet Syndrome(2020) MUMCU, GONCA; Hatemi, Gülen; Meara, Alexa; Ozguler, Yesim; Direskeneli, Haner; Mahr, Alfred; Shea, Beverly; Cam, Esen; Gul, Ahmet; Yazici, Yusuf; Tugwell, Peter; Yazici, Hasan; Merkel, Peter A.; OMERACT Behçet Syndrome Working GroupOBJECTIVE: There is an unmet need for reliable, validated, and widely-accepted outcome measures for randomized clinical trials in Behçet syndrome (BS). The Outcome Measures in Rheumatology Clinical Trials (OMERACT) BS Working Group, a large, multi-disciplinary group of experts in BS and patients with BS, worked to develop a Core Set of data-driven outcome measures for use in all clinical trials of BS. METHODS: The Core Domain Set was developed through a comprehensive, iterative, multi-stage project which included a systematic review, a focus group meeting and qualitative patient interviews, a survey among experts in BS, a Delphi exercise involving both patients and physician-experts in BS, and utilization of the data, insight, and feedback generated by these processes to develop a final Core Domain Set. RESULTS: All steps were completed and domains were delineated across the organ systems involved in this disease. Since trials in BS often focus on specific manifestations and not the disease in its entirety, the final proposed Core Set includes 5 domains mandatory for study in all trials in BS (disease activity, new organ involvement, quality of life, adverse events, and death) with additional sub-domains mandatory for study of specific organ-systems. The final Core Set was endorsed at the 2018 OMERACT meeting. CONCLUSION: The Core Set of Domains in BS provides the foundation through which the international research community, including clinical investigators, patients, biopharmaceutical industry, and government regulatory bodies can harmonize the study of this complex disease, compare findings across studies, and advance development of effective therapies.Publication Metadata only The Assessment of Presenteeism and Activity Impairment in Behcet's Syndrome and Recurrent Aphthous Stomatitis: A multicentre Study(2021) ALİBAZ ÖNER, FATMA; Karacayli, Umit; Adesanya, Adebowale; Aksoy, Aysun; Belem, Joice M. F. M.; Cardin, Natália Borges; Sarı, Fatma Busra; Beyhan, Tuğba Emine; Çelik, Zülal; Karacayli, Ceren; Alibaz-Öner, Fatma; Inanç, Nevsun; Ergun, Tülin; Yay, Meral; Madanat, Wafa; Silva de Souza, Alexandre Wagner; Fortune, Farida; Direskeneli, Haner; Mumcu, GoncaOBJECTIVE: To evaluate key factors for Presenteeism and Activity impairment in multinational patients with Behçet's syndrome (BS) and recurrent aphthous stomatitis (RAS). METHODS: In this cross-sectional study, 364 BS patients from Jordan, Brazil, the United Kingdom and Turkey and 143 RAS patients from the United Kingdom and Turkey were included. Work Productivity Activity Impairment (WPAI) scale was used for Presenteeism and Activity impairment. Mediation analyses were performed to evaluate both direct and indirect causal effects. RESULTS: Presenteeism score was higher in active patients with genital ulcers and eye involvement as well as patients with comorbidities and current smokers than the others in BS (p< 0.05). In RAS, Presenteeism score was elevated by oral ulcer activity in the direct path (p= 0.0073) and long disease duration as a mediator in the indirect path (p= 0.0191).Patients with active joint involvement had poor scores in Absenteeism, Presenteeism, Overall impairment and Activity impairment compared with those of inactive patients (p < 0.05). Using mediation analysis, the Activity impairment score was directly mediated by joint activity (p = 0.0001) and indirectly mediated through oral ulcer-related pain in BS (p = 0.0309). CONCLUSION: In BS, Presenteeism was associated with disease activity, presence of comorbidities and being a current smoker, whereas in RAS, Presenteeism was associated with oral ulcer activity and increased length of the disease. Moreover, Activity impairment was adversely affected by joint activity and oral ulcer related pain in BS. Patients need to be empowered by using appropriate treatment strategies in their working environment and daily life.Publication Metadata only Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health-related Quality of Life in Sjogren Syndrome?(J RHEUMATOL PUBL CO, 2020) MUMCU, GONCA; Yalcinkaya, Yasemin; Mumcu, Gonca; Ozdemir, Filiz Ture; Kurus, Ramazan Esad; Unal, Ali Ugur; Direskeneli, Haner; Bruyn, George A.; Inanc, NevsunObjective. Major salivary gland ultrasonography (SGUS) is a widely used imaging technique to evaluate salivary gland involvement in primary Sjogren syndrome (pSS). The aim of this study was to evaluate the relationship between SGUS, salivary flow rate (SFR) as an objective measure of the gland function, and oral health-related quality of life (OHRQOL) as a patient-reported outcome measure (PROM) in a pSS cohort. Methods. Sixty-six patients with pSS were examined by SGUS according to Hocevar and Milic scoring systems. Patients with inhomogeneity/hypoechoic areas with scores >= 2 in parotid and submandibular glands were classified separately as severe glandular involvement. Further, oral health, SFR, and Oral Health Impact Profile-14 (OHIP-14) for OHRQOL were assessed. Results. Both total Hocevar and Milic scores were higher in 21 pSS patients with low unstimulated whole salivary flow rate (U-WSFR) than 45 pSS patients without low U-WSFR (P = 0.001 and P < 0.0001, respectively). Increased scores of homogeneity, hypoechoic areas and glandular border visibility were observed in patients with low U-WSFR (P < 0.05). Among these variables, homogeneity score was found to be an independent risk factor for low U-WSFR in pSS according to logistic regression analysis (OR 1.586, P = 0.001). Moreover, a higher OHIP-14 score was observed in severe parotid involvement compared to nonsevere cases (23.26 +/- 21.19 vs 8.32 +/- 13.82, P = 0.004). Conclusion. High Milic and Hocevar SGUS scores are associated with reduced SFR and poor OHRQOL as a PROM. The inhomogeneity component of the SGUS score is associated with low U-WSFR and is an indicator of severely affected gland function.Publication Open Access The impact of the COVID-19 pandemic on patients with Behçet's syndrome within the framework of Maslow's hierarchy of needs: Implications for patient empowerment in national or global emergencies(2023-03-02) MUMCU, GONCA; Fortune F., Mather J., Şişman-Kitapci N., Gokani B., Senusi A., Mumcu G.Objective The aim of this online survey was to assess the impact of the COVID-19 pandemic on patients with Behçet’s syndrome (BS) using Maslow’s hierarchy of needs. Methods Sixty-eight BS patients from the UK completed an online questionnaire that covered three components of Maslow’s hierarchy of needs regarding Physiological needs (sleep, food, mobility), Safety needs (employment, health), Social needs (relationships), personal precautions and main concerns regarding COVID-19. Results The patients received a letter from the NHS (66.2%) advising shielding. Health concerns were addressed using Tele-medicine by telephone consultations and e-mails to access BS specialists during lockdown (44.1%; 27.9%). In addition, patients also obtained information through official government and Behçet corporate health web pages related to Behçet’s disease for self-empowerment. During lockdown, their weekly working hours were reduced (26.65±13.86 vs. 20.79±17.94) (p=0.017) and the employment rate was decreased (32.6% vs. 26.7%) in comparison to pre-lockdown. Moreover, the reduction in frequency of exercise per week (4.39±1.94 vs. 3.71±2.26) and healthy food consumption (73.5 % vs. 47.1%) per week were also reported (p=0.007; p=0.001, respectively). Furthermore, patients experienced sleeping less (54.4%) and feeling lonely (66.1%). Conclusion Using Maslow’s hierarchy of needs provided a framework for reviewing the quality of basic needs in patients’ life during lockdown. These needs are required for healthy social lives and the deprivation should be considered while considering healthcare planning. Since lockdown appeared to have a negative influence on patients’ lives and disease management in the framework of patient-centred, the empowerment of patients gained importance at this pointPublication Open Access Readiness for Health Information Technology is Associated to Information Security in Healthcare Institutions(2020) MUMCU, GONCA; Dönmez, Elif; Kitapçı, Nur; Kitapçı, Okan; Yay, Meral; Aksu, Pınar; Köksal, Leyla; Mumcu, GoncaPublication Metadata only Sağlık Teknolojileri ve Değer(Dünya Yayınları, 2022-12-01) MUMCU, GONCA; ÇANDERELİ, ZEHRA ÖZGE; Mumcu G., Çandereli Z. Ö., Beyhan T. E.
- «
- 1 (current)
- 2
- 3
- »