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AKALIN, FİGEN

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AKALIN

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FİGEN

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End date: 2023 × Start date: 2020 ×

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    Constrictive pericarditis diagnosed following liver transplantation
    (MARMARA UNIV, FAC MEDICINE, 2021-10-31) ŞAYLAN ÇEVİK, BERNA; Cetiner, Nilufer; Cevik, Berna Saylan; Tutar, Engin; Erolu, Elif; Koray, A. K.; Akalin, Figen
    Constrictive pericarditis is frequently diagnosed during evaluation of the patients for hepatosplenomegaly and easily missed if not considered in differential diagnosis. Herein, we present a patient diagnosed with constrictive pericarditis during his investigation for impaired liver functions and right heart failure one year after liver transplantation. A thirteen-year-old boy presented with abdominal distention, dyspnea and fatigue. He had undergone liver transplantation due to liver failure in the previous year, and the symptoms had recurred in the last three months. Physical examination revealed normal heart sounds. Abdominal distention and ascites were present. Cardiothoracic index and pulmonary vascular markings were normal on chest X-ray. Echocardiography showed biatrial dilatation. Thickening of the pericardium with calcifications was demonstrated by thorax computerised tomography. High pulmonary wedge pressure and equalization of end-diastolic pressures were found during catheter-angiography. Pericardiectomy was performed, histopathology was compatible with chronic fibrinous pericarditis. The patient improved dramatically after surgery, the right heart failure findings resolved, and the liver graft functions turned to be normal. Constrictive pericarditis must be considered in differential diagnosis of hepatosplenomegaly, liver dysfunction and right heart failure since surgical treatment is possible and lifesaving.
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    PublicationOpen Access
    Evaluation of autonomic nervous system functions by using tilt table test and heart rate variability in epileptic children
    (2023-01-01) AKALIN, FİGEN; Redjepov A., Usta S. A. L. T. U. N. Y. U. V. A., Yildirim Y., AKALIN F.
    Objective: The value of head-up tilt test (HUTT) for differential diagnosis of epilepsy and the autonomic nervous system functions in epileptic children using heart rate variability (HRV) are studied. Patients and Methods: The study group consisted of 16 children with idiopatic/criptogenic epilepsy and 12 controls. Heart rate, PR interval, corrected QT (QTc) interval, QT and QTc dispersion were calculated using 12-lead electrocardiogram (ECG), HRV analysis was performed using the Holter recordings obtained both during HUTT and throughout the day. Time domain parameters, standard deviation of all RR intervals (SDNN), the standard deviation of mean NN intervals in five-minutes recording (SDANN), mean standard deviation of NN intervals in five-minutes recordings (SDNNi), root mean square of successive differences (RMSSD), count divided by the total number of all NN intervals (pNN50) and frequency domain parameters low frequency (LF), high frequency (HF), low-frequency/high-frequency ratio (LF/HF) were calculated in both and compared between the two groups.Results: Head-up tilt test was positive in 4 epileptic children (25%), none of controls were positive. The heart rate of the patients were higher than the controls (p=0.015). LF/HF ratio in 24-hour Holter recordings, were significantly lower (1.13 +/- 0.6, 1.83 +/- 0.7 respectively, p=0.002); the SDANN during HUTT (28.7 +/- 20.2, 18.2 +/- 19.9 respectively, p=0.024) were significantly higher in the patients than the controls.Conclusion: Head-up tilt test positivity is frequent in epileptic children, and cannot be used in differential diagnosis. HRV calculated both from 24 hour Holter recordings and Holter recordings under orthostatic stress were impaired in favour of parasympathetic system in epileptic children.
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    Pulmonary hypertension and obstructive sleep apnea syndrome-Marmara Universitypediatric sleep laboratory experience
    (EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2020) KARADAĞ, BÜLENT TANER; Yegit, Cansu Yilmaz; Ergenekon, Pinar; Eralp, Ela Erdem; Gokdemir, Yasemin; Akalin, Figen; Yildirim, Ayse; Sabanci, Meltem; Karadag, Bulent
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    Konjenital kalp hastalığının Nkx2-5 gen varyantları ile ilişkisi
    (2022-11-13) GEÇKİNLİ, BİLGEN BİLGE; AKALIN, FİGEN; ARMAN, AHMET; Geçkinli B. B., Demir Ş., Girgin Özgümüş G., Türkyılmaz A., Akalın F., Arman A.
    Konjenital kalp hastalığı (KKH), doğumsal anomalilerin en sık görülen şeklidir. Yenidoğanda yaklaşık %1 sıklıktadır ve doğumsal anomaliler içinde çocuk ölümlerinin en sık sebebidir. KKH etyolojisi çoğu vakada tam belirlenememiştir. Embriyogenezde anormal kalp gelişimindeki biyolojik süreç heterojen ve komplekstir, hem çevresel ve hem de genetik risk faktörlerini içerdiği düşünülmektedir. Bu çalışmada KKHda moleküler etiyolojiyi aydınlatmak için NKX2- 5 genindeki varyantların DNA dizi analizi ile saptanması hedeflenmiştir. Çalışmamızda KKH tanısı alan 80 hasta ve 50 kontrol grubu incelenmiştir. Kromozom anomalisi, Digeorge sendromu ve multipl konjenital anomalileri olan hastalar dahil edilmemiştir. Hastalarda ventriküler septal defekt (VSD) %23, atrial septal defekt (ASD) %20, Fallot tetralojisi (TOF) %11, atrioventriküler septal defekt, pulmoner atrezi ve aort quarktasyonu %10 oranında mevcuttu. Sırasıyla ASD ve patent foramen ovale saptanan hastalarda missense tanımlı heterozigot p.C270Y ve p.R161P varyantları saptandı. p.C270Y olası benign, VUS (Variant of unknown significance) ve p.R161P KKH’nın eşlik edebileceği konjenital hipotiroidi ile ilişkili patojenik varyant olarak tanımlıdır. Segregasyon analizi için yapılan ebeveyn taramasında taşıyıcılık saptanmıştır. Türk toplumunda KKH patogenezinde varyantların saptanması, dünya çapında bu zamana kadar tespit edilen varyantlar ile kıyaslanması ile etnik kökene göre varyant farklılığının etkisi belirlenebilecektir. Böylelikle KKH tedavisine yönelik çalışmaların ilerlemesine katkı sağlanarak morbidite ve mortalite azalacaktır. Bu çalışma Marmara Üniversitesi, Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje Kodu: SAG-B -070317- 0085 Anahtar Kelimeler: Konjenital kalp hastalığı, NKX2-5 geni, kardiyak transkripsiyon faktörü