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ALKAN, ELİF

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ALKAN

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ELİF

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    PublicationOpen Access
    Evaluating the effects of different remineralization agents on initial enamel lesions in vitro
    (2022-04-23) ALKAN, ELİF; YILMAZ ATALI, PINAR; TAĞTEKİN, DİLEK; SARIALİOĞLU GÜNGÖR A., DALKILIÇ E., ALKAN E., YILMAZ ATALI P., TAĞTEKİN D.
    Aim: Disruption of the demineralization–remineralization balance could activate the development of initial enamel lesions. Extrinsic assistance is needed to remineralize enamel lesions. The aim of this study was to evaluate the efects of fuoride varnish, enamel matrix proteins derivative, and experimental bioactive glass (BAG) on remineralization of initial enamel lesions in vitro. Materials and Methods: Artifcial initial caries lesions were developed on ffty human enamel samples using demineralization solution (pH 4.5, 37°C, 96 hours). Samples were randomly assigned to 5 groups (n=10): I-Fluoride varnish (Enamelast), II-Experimental BAG + 37% phosphoric acid (PA), III-Enamel matrix proteins derivative (EMPD, Emdogain) +Ethylenediamine-Tetraacetic-Acid (EDTA), IVEMPD+37% PA, V-Control (untreated). All remineralization agents were applied with pH cycling for 7 days. The samples were scanned by optical coherence tomography (OCT) at baseline, demineralization, and after pH cycling. Lesion depths were measured using image analysis software (ImageJ). Lesions were evaluated using surface microhardness (SMH) and two fuorescence methods (FluoreCam® and DIAGNOdent Pen (DDPen)). The data were statistically analyzed by Kruskal Wallis, Friedman, and Wilcoxon tests (p<0.05). Results: According to OCT results, fuoride varnish was found to be the most efective agent in reducing lesion depth (p=0.005). Depending on SMH results, all agents increased the surface hardness values after pH cycling. No signifcant diference was found among fuoride varnish, BAG, and EMPD+PA groups. And these microhardness values were signifcantly higher than EMPD+EDTA and control groups (p<0.001). According to the DDPen score criteria, all groups showed lower scores compared with the control group (p<0.001), however, Clinical Oral Investigations (2022) 26:7299–7348 7317 1 3 no signifcant diference was found among the remineralization agent groups. In FluoreCam assessment, size and intensity values of all treated groups showed improvement. However, there was no signifcant diference between the treatment groups in terms of FluoreCam-size measurements (p=0.186). Conclusion: BAG and EMPD+PA has a remineralization capacity as much as fuoride varnish. EMPD+PA showed better microhardness and lesion intensity results than EMPD+EDTA.