Person: ARMAN KANDIRMAZ, EMİNE
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ARMAN KANDIRMAZ
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Publication Metadata only Aprepitant in the Treatment of Subacute Sclerosing Panencephalitis: A Randomized, Double-Blind, Placebo-Controlled Study(ELSEVIER SCIENCE INC, 2020) ARMAN KANDIRMAZ, EMİNE; Oncel, Ibrahim; Sancar, Mesut; Konuskan, Bahadir; Arioz, Filiz; Tezcan, Songul; Arman-Kandirmaz, Emine; Parlak, Safak; Gumeler, Ekim; Anlar, BanuBackground: Aprepitant is a neurokinin-1 receptor antagonist approved for the treatment of chemotherapy-induced nausea. We aimed to investigate the safety and efficacy of aprepitant in patients with subacute sclerosing panencephalitis. Methods: A randomized, double-blind, placebo-controlled study was conducted in patients with subacute sclerosing panencephalitis assigned to receive two courses of aprepitant 250 mg/day orally or placebo for 15 days with an interval of two months between courses. Primary end points were safety and tolerability, and secondary end point was clinical improvement or stabilization assessed by subacute sclerosing panencephalitis scoring system. Electroencephalography (EEG), brain magnetic resonance imaging, and cerebrospinal fluid measles-specific immunoglobulin G index were evaluated before and after treatment. Results: Sixty-two patients with subacute sclerosing panencephalitis were allocated to aprepitant (n = 31, median age 18 years) or placebo (n = 31, median age 22 years) group. Fifteen patients left the study within the first six months and 12 patients left between six and 12 months. Aprepitant was well tolerated and treatment-associated adverse events were similar to those described in the treatment of nausea. Clinical status at six and 12 months' follow-up did not differ between aprepitant and placebo groups. Post-treatment EEG scores at 12 months were better in the aprepitant group (P = 0.015). Cerebral atrophy on magnetic resonance imaging increased in both groups, whereas measles-specific immunoglobulin G index decreased in the placebo group. Conclusions: In this first clinical trial of aprepitant treatment in patients with subacute sclerosing pan encephalitis, the drug was safe and well tolerated. No clinical effect was observed. A modest improvement in EEG findings might justify trials for longer periods because EEG changes can precede clinical findings in subacute sclerosing panencephalitis. (C) 2020 Elsevier Inc. All rights reserved.Publication Metadata only Preparation of novel thioxanthone based polymeric photoinitiator for flexographic varnish and determination of their migration behaviour(ELSEVIER SCIENCE SA, 2018) GENÇOĞLU, EFE NEJAT; Kandirmaz, Emine Arman; Apohan, Nilhan Kayaman; Gencoglu, Efe N.Today, polymeric photoinitiators are good choice for initiation mechanism of UV-curable printing inks with their low migration potential. In this study, new thioxanthone-styrene polymeric photoinitiators were synthesized. Polystyrene that was synthesized by atom transfer radical polymerization (ATRP) was functionalized by cyclohexeneoxide and then reacted with thioxanthone-thioacetic acid. Piperazine was reacted with bromine chain end of polystyrene and final polymeric photoinitiator was obtained. Proton Nuclear Magnetic Resonance (H-1 NMR), Attenuated Total Reflectance- Fourier Transform Infrared Spectroscopy (ATR-FTIR), Gel Permeation Chromatography (GPC) and Ultraviolet-Visible Spectroscopy (UV-vis) analyses were confirmed the expected structures. The curing property of new polymeric photoinitiator was compared with a conventional thioxanthone printing formulation that is used in flexographic varnish. The photopolymerization kinetics were determined by Photo Differential Scanning Calorimetry (Photo-DSC) and the results showed that 83% of conversion was reached for thioxanthone-styrene polymeric photoinitiator with MW = 4200. The migration behavior was identified with Liquid Chromatography-Mass Spectrometry LC-MS. It was shown that thioxanthone based polymeric photoinitiator is usable in flexographic varnish and thioxanthone migration level is reduced with macrophotoinitiation.Publication Metadata only The Synthesis of New Type II Polymeric Photoinitiator (thioxantone) via Atom Transfer Radical Polymerization and Their Curing and Migration Studies(POLYMER SOC KOREA, 2019) GENÇOĞLU, EFE NEJAT; Kandirmaz, Emine Arman; Gencoglu, Efe N.; Apohan, Nilhan KayamanPolymeric photoinitiators are widely used in ultraviolet (UV)-curable printing inks because of their low migration behavior. In this study, a new phenylphosphine oxide-polystyrene-thioxanthone (PPO-PSt-TX) polymeric photoinitiator was synthesized. Bis[(4-hydroxy)phenyl]phenyl phosphine oxide (BHPPO) that was synthesized by Grignard technique, was functionalized with 2-bromopropionyl bromide (atom transfer radical polymerization (ATRP) initiator) and then used in styrene polymerization. The bromine end-capped polystyrene was then reacted with 2-thioxanthone-thioacetic acid and final polymeric photoinitiator PPO-PSt-TX was obtained. Proton nuclear magnetic resonance (1H NMR), attenuated total reflectance- Fourier transform infrared spectroscopy (ATR-FTIR), gel permeation chromatography (GPC) and ultraviolet-visible spectroscopy (UV-Vis) confirmed the obtained structure. The curing characteristic of PPO-PSt-TX was compared with a standard flexographic printing varnish formulation containing thioxanthone (TX). The photopolymerization kinetics were determined by photo differential scanning calorimetry (Photo-DSC). The conversion of methylmethacrylate polymerization by using macrophotoinitiator is 78%. The migration behavior of PPO-PSt-TX was identified with liquid chromatography-mass spectrometry (LC-MS). It was shown that PPOPSt- TX macro photoinitiator is suitable for flexographic varnish and the migration level of photoinitiator is reduced by using polymeric photoinitiator.Publication Open Access Nisin ve Sodyum Aljinat İçeren Kağıt Kaplamalarının Hazırlanması ve Antimikrobiyal Özelliklerinin İncelenmesi(2020-04-15) ARMAN KANDIRMAZ, EMİNE; Emine ARMAN KANDIRMAZSon yüzyılda artan dünya nüfusu ve çevre kirliliğinin sonucu olarak gıda kaynaklarındaki azalmalar doğal ve işlenmiş gıdaların muhafazasını daha da önemli hale getirmiştir. Bu kapsamda yeni işleme teknolojileri yanında daha uzun raf ömrü sağlayan ambalaj ve depolama tekniklerinin geliştirilmesi gerekmektedir. Biyopolimerlerden elde edilen yenilebilir kaplamalar; doğal, ucuz ve çevre dostu özelliklerinden ötürü son yıllarda gıda ambalajlama materyali olarak sıklıkla kullanılmaktadır. İyi kaliteye sahip yenilebilir bir malzemenin; duyusal özellikleri (şeffaf, tatsız ve kokusuz) yanında bariyer özellikleri (nem, oksijen geçirgenlikleri), gıda ile malzeme ve/veya atmosfer ile malzeme arasında gerçekleşebilecek fiziksel ve biyokimyasal reaksiyonlara karşı kararlı yapıda olması, sağlık açısından güvenilir, çevreyle dost ve düşük maliyetli olması önemlidir. Yenilebilir filme antimikrobiyal özellikler kazandırılarak daha uzun ömürlü gıda koruması gerçekleştirilebilmektedir. Gıdalara raf ömrü artırmak amacıyla antimikrobiyal özellik gösterdiği bilinen maddeler; nisin, natamisin, askorbik asit veya sodyum aljinat sayılabilmektedir. Bu çalışmada nisin ve sodyum aljinat ve bunların ikili karışımlarının dolgu maddesi olarak eklendiği nişasta bazlı kâğıt kaplama formülasyonları hazırlanmıştır. Elde edilen biyokaplamaların kimyasal yapısı ATR-FTIR ile aydınlatılmıştır. Biyokaplamaların renk, parlaklık, temas açısı ve yüzey morfolojisi belirlenmiştir. Elde edilen boş, nisin katkılı, sodium aljinat katkılı ve nisin-sodyum aljinat katkılı nişasta biyokaplamaların antimikrobiyal özellikleri Listeria Monocytogenes gram pozitif ve Escherichia coli gram negatif bakterileri üzerinde incelenmiştir. Elde edilen kaplamalara magenta renkli mürekkep ile IGT C1 ofset basılabilirlik test baskı makinası ile baskılar yapılmış ve elde edilen baskıların renk ve parlaklık değişimleri incelenmiştir. Sonuç olarak antibakteriyel biyokaplamalar başarıyla üretilmiştir. İçerisine dolgu maddesi olarak gıda koruyucu içeren filmlerde bakteri üremesini azaltma oranları nisin-sodyum aljinat katkılı nişasta biyokaplama ˃ sodyum aljinat katkılı nişasta biyokaplama ˃ nisin katkılı nişasta biyokaplama şeklinde sıralanabilir.Publication Metadata only Thermal, optical and electrical properties of UV-curing screen-printed glass substrates(SPRINGER, 2019) ARMAN KANDIRMAZ, EMİNE; Cigil, Asli Beyler; Kandirmaz, Emine Arman; Birtane, Hatice; Kahraman, Memet VezirIn this study, the hydroxyl functionality of the polyaniline surface was obtained using hydroxyethyl methacrylate and acrylated with isocyanatoethyl methacrylate. Coating formulation being curable with UV was designed by mixture of acrylated PANI (a-PANI) (0-5wt%), polyethylene glycol diacrylate, trimethylolpropane triacrylate, hydrolyzed 3-(methacryloxy) propyl trimethoxysilane (hydMEMO) and photoinitiator. The hybrid composite formulation has been printed on the glass surface with the method of screen printing. The chemical structure and the properties of thermal, electrical and surface obtained products were determined with ATR-FTIR, goniometer, current-voltage meter, scanning electron microscopy (SEM) and thermogravimetric analysis. ATR-FTIR results have shown that all materials were clearly produced. SEM results have revealed that PANI was dispersed at the composite in a stable manner. The conductivity value of the conductive line printed with F5a-PANI was found to be 3.7x10(-3)S. The best electrical results have presented that PANI has been beneficial for conductive line, and thus, screen printing was a convenient method for printing conductive lines.Publication Metadata only Therapeutic drug monitoring of aprepitant with liquid chromatography–massspectrometry(2023-10-31) TEZCAN, SONGÜL; ARMAN KANDIRMAZ, EMİNE; SANCAR, MESUT; TEZCAN S., Kunal G., ÖZDEMİR F., ARMAN KANDIRMAZ E., SANCAR M.Publication Open Access Potential of fish scales as a filling material in surface coating of cellulosic paper(2018-01) URAL, ELİF; Ural, Elif; Kandirmaz, Emine A.Background: Paper is one of the important inputs for the printing industry, and the most important leading parameter in the printing process is its brightness. Brightness can be brought to paper using coatings and sizing. Desired surface properties and, most importantly, surface roughness can be achieved by changing the contents of the coating and sizing of the materials it contains. The use of biomaterials is becoming more important in the paper industry, as they represent substances with a lower carbon footprint. Fish scales are already used as a filling material, cosmetic material and fish food, as well as for determining the age of fish. Methods: Fish scales were brought to different sizes by a milling process. Paper formulations including different amounts of fish scales were prepared with fish scales, and coatings on raw paper were subjected to test printings in IGT-C1, with formulations and physical characteristics of coatings such as brightness, lightfastness, strength, adhesion etc. being determined. Results: Regarding the value of yellowness, mixtures of 2.5%-10% can be used. The maximum value of brightness was obtained from a mixture of 10%. Aging visibly changed the colors. Conclusions: The coatings obtained were brighter than the initial coating compositions. The top quality formulation was the coating with 5% medium-sized fish scale particles.Publication Metadata only The effect of paper coatings containing biopolymer binder and different natural pigments on printability(De Gruyter Open Ltd, 2021) ÖZCAN, ARİF; Arman Kandirmaz E., Ozcan A., Ural E.Paper is an environmentally friendly, recyclable material whose main material is cellulose, which can be obtained from all kinds of trees and plants, used as writing, printing and packaging material. Due to its structural properties, papers are not resistant to temperature and humidity, as well as problems with ink transfer with its porous structure and experienced negative printability properties. In recent years, especially the growth of the packaging industry has increased the demand for papers with improved printability properties. In order to obtain better printability properties from papers, some processes can be performed in paper production, as well as some surface treatments after production. These processes are paper coating, sizing and calendering. Paper coatings are generally water-dispersed coating solutions with one or more pigments, binders and certain additives to improve the desired properties. With these processes, by filling the gaps between the pores of the paper, a shapely and smooth surface is obtained and good printability is obtained together with the optical and physical properties of the papers. In this study, the interactions and printability properties of different types of pigments with xanthan gum binder were investigated by preparing paper coating formulations using calcium carbonate, barite and talc pigments and xanthan gum as binder. As a result, xanthan is a good coating binder and CaCO3 from the compared pigments is the most suitable compared to the other 2 pigments, considering all the studied areas. © 2021 Walter de Gruyter GmbH, Berlin/Boston.Publication Metadata only Antibacterial effect of Ag nanoparticles into the paper coatings(WALTER DE GRUYTER GMBH, 2019) ÖZCAN, ARİF; Kandirmaz, Emine Arman; Ozcan, ArifFood packaging is the most important output of the printing industry. Giving antibacterial effect to the papers used in food packaging will extend the shelf life of the product and food transfer in healthier conditions. The nanoparticles with known antibacterial activity are nanosilver, nanogold, nanosilica. Binders used in paper coating provide a good nutrient medium for bacteria. In this study, Ag nanoparticles was first synthesized as monodisperse in 10 nm size with polyvinyl pyrrolidone and sodium boron reaction which will give antibacterial properties to paper coatings. The chemical structure of the synthesized Ag nanoparticles is illuminated by fourier transform infrared spectrophotometer (FTIR). Different paper coating formulations containing varying amounts of Ag nanoparticles were prepared with starch binder. Using these mixtures; papers coated with a laboratory-type paper coating machine onto 80 g/m(2) paper. Color, gloss, contact angle, surface energy, antibacterial properties of the paper against the E. coli bacteria and S. aureus bacteria were examined. As a result, Ag nanoparticles has been successfully synthesized and used in paper coating. Antibacterial and printability properties were improved by increasing the amount of Ag nanoparticles.Publication Open Access Chitosan-titanium nanoparticle coated papers for active packaging(2023-11-01) ÖZCAN, ARİF; ARMAN KANDIRMAZ, EMİNE; ÖZCAN A., ARMAN KANDIRMAZ E., Acar Buyukpehlivan G.In this study, it was aimed to increase the antimicrobial properties by combining chitosan and titanium nanoparticles. First, titanium nanoparticles were synthesized by sol-gel method and nanoparticles were modified with thiol groups. The chitosan has been modified with allyl glycidyl ether. Both obtained molecules were linked to each other by a thiol-ene click reaction. The chemical structure of the obtained chitosan modified titanium nanoparticles was elucidated by ATR-FTIR. Paper coating formulations were prepared by using the produced nanoparticles and hydroxy ethyl cellulose at different rates and applied on the base paper. Color, gloss, surface energy, contact angle, air permeability properties of the papers were determined by spectrophotometer, glossmeter, goniometer and L&W air permeability device, respectively. Screen prints were made on coated papers and their printability properties were examined. Antimicrobial properties of titanium nanoparticles, chitosan and chitosan modified titanium nanoparticles were determined against E. coli and S. aureus by disk diffusion method. As a result, it has been determined that both titanium and chitosan have antimicrobial properties against both bacterial species separately and the produced chitosan modified titanium nanoparticles increase this antimicrobial property more having a synergetic effect. It has been concluded that the produced antimicrobial papers have a high upside to be active packaging printing material.
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