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ATALAN ÖZLEN, NAZAN

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ATALAN ÖZLEN

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NAZAN

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    PublicationOpen Access
    The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level
    (INT INST ANTICANCER RESEARCH, 2018) ATALAN ÖZLEN, NAZAN; Atalan, Nazan; Acar, Leyla; Yapici, Nihan; Kudsioglu, Turkan; Ergen, Arzu; Yilmaz, Seda Gulec; Isbir, Turgay
    Background/Aim: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels. Materials and Methods: The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded. Results: TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher. Conclusion: There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system.