Person: OMURTAG KORKMAZ, BURCU İREM
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OMURTAG KORKMAZ
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BURCU İREM
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Publication Metadata only Antimicrobial effects of stinging nettle (urtica dioica L.) extracts on campylobacter jejuni(2021-03-28) OMURTAG KORKMAZ, BURCU İREM; Aydın H. B., OMURTAG KORKMAZ B. İ.Stinging nettle (Urticadioica L.) is a perennial plant from the Urticaceae family, whose leaves and stem are covered with irritating hairs. It grows wild in Europe, North America, North Africa and West Asia and in every region of our country. U. dioica; regard to its rich nutritional value and essential oils, phenolic compounds and flavonoids, has been used both as a food and traditionally for healing since years. Campylobacter jejuni is a gram-negative bacterium that causes infections especially in poultry meat, meat products, raw milk, contaminated water, and foodborne infections. It is a common cause of diarrhea cases in developing countries and sporadic gastroenteritis in developed countries around the world. C. jejuni produces adenylate cyclase activating toxin, causing "campylobacter gastroenteritis". It is also a notable pathogen in terms of infection control, due to its association with severe neuropathological sequelae such as, GuillainBarré, Reiter syndromes, and cases of bacteremia. C. jejuni, which can rapidly develop resistance to antibiotics used for infection control, poses a global risk to human health and increases the need for the development of antimicrobials with different mechanisms of action.In today's agriculture and food industry, natural and safe antimicrobials are needed with the widespread use of antibacterials and increased bacterial resistance to existing antibiotics for the control of microorganisms that pose a global health risk in the medical field. For this reason, U. dioica is often under investigation for its antimicrobial effects. In the literature, extracts of U. dioica against food-borne Campylobacter jejuni, Pseudomonas, Shigella spp., Bacillus cereus, Staphylococcus aureus, Vibrio parahaemolyticus, and Escherichia coli; hospital acquired, Staphylococcus aureus, Bacillus subtilis, Salmonella spp. and there are data showing antimicrobial activity on methicillin-resistant Staphylococcus auerus (MRSA). In disk diffusion analysis, it was found that U. dioica ethanolic extract exhibited antimicrobial effects on C. jejuni. It has been determined that tinctures of U. dioica have a minimum inhibitory concentration of 3.125% against C. jejuni. By using U. dioica extract as a strategy to combat infections, it seems to be important revealing its potential of inhibitionPublication Metadata only Midye dolmadaki mikrobiyolojik tehlikeler ve gramaj analizi(2018-05-03) OMURTAG KORKMAZ, BURCU İREM; OMURTAG KORKMAZ B. İ., KORKMAZ S.Publication Open Access Using microbial responses viewer and a regression approach to assess the eEffect of pH, activity of water and temperature on the survival of campylobacter spp(2022-03-01) OMURTAG KORKMAZ, BURCU İREM; İÇEN, HAYRUNİSA; İÇEN H., Corbo M. R., Sinigaglia M., OMURTAG KORKMAZ B. İ., Bevilacqua A.This study aimed at developing a model for evaluating the survival of various Campylobacter jejuni strains under different conditions in culture media and poultry data from ComBase. Campylobacter data of culture media (116) and poultry (19) were collected from Microbial Responses Viewer, an additional tool of ComBase. The Weibull equation was selected as a suitable model for the analysis of survival data because of the nonlinearity of survival curves. Then, the fitting parameters (first reduction time and shape parameter) were analysed through a Kruskall-Wallis test and box-whisker plots, thus pointing out the existence of two classes of temperature (0-12 degrees C and 15-25 degrees C) and pH (4-6.5 and 7-7.5) acting on the viability of C. jejuni. Finally, a general regression model was used to build a comprehensive function; all factors were significant, but temperature was the most significant variable, followed by pH and water activity. In addition, desirability and prediction profiles highlighted a negative correlation of the first reduction time with temperature and a positive correlation with pH and water activity.Publication Open Access Microbiology and antimicrobial effects of kombucha, a short overview(2023-12-01) İÇEN, HAYRUNİSA; OMURTAG KORKMAZ, BURCU İREM; İÇEN H., Corbo M. R., Sinigaglia M., OMURTAG KORKMAZ B. İ., Bevilacqua A.Kombucha is a beverage usually prepared with black or green tea containing sucrose, and a synbiotic culture of bacteria and yeasts (SCOBY). This paper aims at offering an overview on kombucha microbiota, as well as on its nutritional composition, and antimicrobial effects. The microbiota of kombucha includes acetic acid bacteria (Acetobacter, Gluconobacter, Gluconacetobacter, Komagataeibacter), lactic acid bacteria (Lactobacillus, Lactiplantibacillus, Lacticaseibacillus) and yeasts (Brettanomyces, Candida, Saccharomyces, Zygosaccharomyces), depending on raw materials, starter cultures, and fermentation temperature. The second topic of this review is the production path and kombucha composition, with a synopsis from a quali-quantitative point of view of the most important compounds. Finally, the review examines the antimicrobial potential, focusing on both Gram-positive and Gram-negative bacteria. An open question is on the probiotic status of kombucha; this review offers a contribution to this debate, suggesting for this beverage the status of post-biotic.Publication Metadata only Gıda kaynaklı hastalıklarda risk değerlendirmesi(2018-04-12) OMURTAG KORKMAZ, BURCU İREM; OMURTAG KORKMAZ B. İ.Publication Open Access The effects of solutions of maca (Lepidium meyenii) powder as a food/feed supplement on the viability of murine macrophage cells by digital image analysis(2021-01-01) OMURTAG KORKMAZ, BURCU İREM; KORKMAZ S., Parmaksız A., SAİT A., OMURTAG KORKMAZ B. İ.Maca (Lepidium meyenii) is a tuber root plant and belong to Brassicaceae family and recently used as a supplement in human and animal nutrition. In this study, it was aimed to investigate the cytotoxicity of two solutions (aqueous and ethanol) of maca root powder by digital image analysis. Maca powder was mixed in ultra distilled water and ethanol (1:2 w/v) for 24 h at 4 °C. The mixtures were centrifuged and the supernatants were ten-fold diluted for cytotoxic analysis of Raw 264.7 murine macrophage cells. After seeded the cell cultures in microplates, ten-fold dilutions (from 10-1 to 10-7 ) of both maca solutions were added as six replicates for 24 h. While the aqueous maca solution increased the number of dead cells at 10-1 (50 mg mL-1 ), the ethanolic solution statistically increased the number of dead cells at 10-1 , 10-2 and 10-3 (50, 5 and 0.5 mg mL-1 ) (P<0.01). In conclusion, the alcoholic preparation of maca powder caused a higher cytotoxic effect on the murine macrophage cells than the aqueous preparation due to the solvents and the dilution factor in this study.Publication Open Access Antibacterial and antiviral activities of stinging nettle (urtica dioica l.) leaf extract on norovirus and campylobacter jejuni as foodborne pathogens(2023-05-01) OMURTAG KORKMAZ, BURCU İREM; Aydin H. B., Korkmaz S., OMURTAG KORKMAZ B. İ.Research background. The cytotoxicity on various vital cell lines and the activity on foodborne pathogens (murine norovirus 1 as a norovirus surrogate and Campylobacter jejuni) of methanolic Urtica dioica L. leaf extract (UDE) were studied. Experimental approach. The cytotoxic concentration of 50% (CC50) was measured by the linearity between UDE concentrations and cell viability. Antibacterial effects on C. jejuni were analyzed by the broth microdilution method with a spectrophotometer. The virucidal and antiviral activities of UDE were determined by the virus titration method on the host cell infectivity and expressed as the tissue cell infective dose of 50% using the method of Spearman-Karber. Results and conclusions. The CC50 of UDE was determined on macrophage as the virus host cell. MIC and MBC of UDE were determined as 5 mg/ml and 20 mg/ml for both C. jejuni isolated from poultry meat and the standard strain. UDE inhibited MNV-1 on three pathways of host cell infectivity at approximately the same 50% inhibitory concentration (1.45-1.87 mg/ml). In conclusion, the present study tried to explain in detail the dose-dependent activity of Urtica dioica L. leaf extract on two important foodborne pathogens causing outbreaks worldwide. The results showed that it might be a safe and alternative food additive and supplement candidate at safe concentrations.Publication Metadata only Virucidal activity of xanthan gum and carboxymethyl cellulose as thickener and emulsifier additives in production technology(2022-02-23) OMURTAG KORKMAZ, BURCU İREM; KORKMAZ S., Parmaksız A., SAİT A., OMURTAG KORKMAZ B. İ.Publication Open Access Evaluation Of healthy nutrition index-2015, dental health and oral flora relationship in school-age children(2021-10-01) KARĞIN, DİCLE; OMURTAG KORKMAZ, BURCU İREM; KARĞIN D., OMURTAG KORKMAZ B. İ., MUNGAN C., AKYÜZ S. H.Objective: The aim of the study is to evaluate the role of diet quality and oral flora on the dental health in the childhood period. Methods: A cross-sectional study was carried out with the participation of 98 children aged 9-14 and their parents who applied to the Pedodontics Clinic Dental Faculty of Marmara University. The decayed, missing, filled tooth and surfaces and DMFT, DMFS indexes were determined through visual dental examination. Anthropometric measurements and saliva samples, as well as 24 h food consumption records, were taken from each child. Saliva samples were analysed microbiologically. To evaluate dietary quality from intakes Healthy Eating Index-2015 (HEI-2015) scores were calculated. Results: The mean age of children was 10.8±1.5 and study sample compromised 44.9% males and 55.1% females. 75% of the children had normal height and 58.2% of them had normal BMI according to World Health Organisation (WHO) references. The mean number of decayed tooth and surface was 3.07±2.35; 4.34±3.78 respectively and the mean number of DMFT and DMFS indexes were 5.88±2.31; 8.05±4.58 respectively. The mean number of decayed, missing, filled teeth and DMFT, DMFS scores were found to be higher in children with poor diets (according to HEI-2015) but the difference was not statistically significant (p>0.05). The presence of lactobacilli in saliva samples of 5.5% of the children was observed and children have lactobacilli in their saliva samples had more decayed teeth (p<0.05). Conclusion: The study findings illustrate the relationship between decay development and lactobacilli. Further studies with high sample sizes are needed to examine the diet quality and oral health.Publication Metadata only Camellia sinensis ekstraktının lactobacillus plantarum ve escherichia coli gelişimi üzerine etkisinin incelenmesi(2021-12-25) OMURTAG KORKMAZ, BURCU İREM; Taş K., OMURTAG KORKMAZ B. İ.
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