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TACAL ASLAN, BESTE

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TACAL ASLAN

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BESTE

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    PublicationOpen Access
    Investigation of the Relationship between Anxiety Disorder and Time Perception with DRD2 rs1800497 Polymorphism
    (2022-10-01) ULUCAN, KORKUT; TACAL ASLAN, BESTE; San H. O. , Tarlacı S., Ulucan K., Polat T., Yılmaz Ö. Ö. , Tacal Aslan B.
    We have many biological systems that regulate the perception of time, which is one of our most essential abilities that allows subjectively predicting, perceiving and understanding the duration of experiences, feelings and achievements. There are findings obtained from many studies aiming to illuminate the place and importance of time, which was the most critical reference point for human understanding of life in the past, for us mammals. According to these findings, it is observed that there is a similar mechanism that provides the perception of time in almost every living organism. Time perception is vital for the healthy functioning of cognitive activities, physiological needs and behavioral relations, and the bio-psycho-social order's systematicity. Among the studies conducted, the findings obtained in the studies related to the effect of psychiatric disorders on the perception of time are somewhat blurry compared to the others. The research for this study was based on six basic Polymorphisms known to affect time perception and internal clock mechanisms. These are as follows: SLC6A4 / 5-HTTLPR, 5HT2A / T102C, DRD2 / TAQ1A, SLC6A3 / 3UTR VNTR, COMT / VAL158MET, GABRB2 A/C, CLOCK. In our study, the relationship between the rs1800497 polymorphism, which is one of these seven polymorphisms that are effective in the functioning of the internal clock in the human brain, and the inventory used in the measurement of anxiety, was examined in 14 participants. Beck Anxiety Inventory (BAI) was used to measure anxiety, and PCR was used to detect genetic variants. When the findings were evaluated, no significant relationship was found between anxiety and DRD2 rs1800497 polymorphism.
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    PublicationOpen Access
    Preliminary findings of the distribution of alpha-2-adrenergic receptor (ADRA2A) rs1800544 polymorphisms in kickboxing players
    (2021-12-01) TACAL ASLAN, BESTE; OKTAY, NİHAL ŞEHKAR; ULUCAN, KORKUT; Eken B. F., Savcı A. A., Polat T., Yılmaz Ö. Ö., Silar C., TACAL ASLAN B., OKTAY N. Ş., ULUCAN K.
    Objective: Adrenergic receptors play an important role in providing neurotransmitter release from the sympathetic nervous system and adrenergic neurons. The rs1800544 polymorphism in 3’-untranslated region of Alpha-2-Adrenergic Receptor (ADRA2A) is if caused by C>G tranversion at position –1291. In this study, we objective to analyze the rs1800544 distribution in kickboxing players. Methods: A total of 12 male players and 101 sedentary individuals (as a control group) participated in the study. Following DNA isolation, rs1800544 polymorphism of ADRA2A gene was determined by real-time polymerase chain reaction (Rt-PCR). Statistical analysis was carried out by chi-square test. Results: CC, CG and GG genotypes and percentages for rs1800544 polymorphism were analyzed as 5 (41,7%), 4 (33,3%) and 3 (25%), respectively. C allele was counted as 14 (58,3%) and G allele as 10 (41,7%). In the control group CC, CG and GG were found as 34 (33,6%), 53 (52,5%), 14(13,9%), respectively. C allele was counted as 121 (60%) and G allele as 81 (40%). When we compare athletes and controls in the terms of genotypes, we detected no statistically significant difference (p>0,3940). For the allele comparison, we detected no significant difference between groups (p>0,0871). Conclusion: Determination of gene combinations in athletes is of great importance for determination of the effect of genetic factors in athletic performance. In our cohort, CC genotype was more frequently found, and C allele was also higher in players. We think that the effect of ADR2A2 gene on athletic performance might be determined more clearly by the fact that this study is an example of similar studies involving higher numbers of subjects.
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    PublicationOpen Access
    Sprint and Anaerobic Power with the Soccer-Specific ACTN3 Gene: A Distintive Example
    (2024-03-01) TACAL ASLAN, BESTE; POLAT, TOLGA; YILMAZ, ÖZLEM ÖZGE; ULUCAN, KORKUT; Söyler M., Zileli R., Özkamçı H., Diker G., Sever M., Bayrakdaroglu S., Ön S., Can İ., Ulucan K., Tacal Aslan B., et al.
    The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur soccer players, and (2) to determine whether there is a difference in theACTN3gene polymorphism between professional and amateur soccer players. Ultimately, the goal is to reveal which parameters contribute to the differentiation in these two aspects. A total of 133 volunteer soccer players, including 71 professionals and 62 amateurs, participated in the research. DNA extraction from buccal epithelial cells was performed using a commercial kit to determine the genetic background of the athletes, and Real-Time PCR was conducted for genotyping. Statistical analysis of the findings obtained from the test results was performed using the SPSS 23 (SPSS Inc., Chicago, IL, USA) package program. The homogeneity of variance of the data was assessed using the Levene Test, and normal distribution analyses were conducted using the Shapiro-Wilk Test. Chi-square and Mann-Whitney U tests were employed for parameter analysis. The significance level was set at p<0.05. Evaluation of the data in our study revealed no statistically significant difference inACTN3rs1815739 gene polymorphism between the groups (p>0.05). However, there is a statistically significant difference in anaerobic parameters (10m sprint, 30m sprint, and anaerobic power) except for the Illinois test (p<0.05). In conclusion, our study found that gene polymorphism is not a differentiating factor between professional and amateur soccer players, but speed (10m and 30m) and anaerobic power parameters are differentiating factors.