Publication: Investigation of the Relationship between Anxiety Disorder and Time Perception with DRD2 rs1800497 Polymorphism
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Date
2022-10-01
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Abstract
We have many biological systems that regulate the perception of time, which is one of
our most essential abilities that allows subjectively predicting, perceiving and
understanding the duration of experiences, feelings and achievements. There are
findings obtained from many studies aiming to illuminate the place and importance of
time, which was the most critical reference point for human understanding of life in
the past, for us mammals. According to these findings, it is observed that there is a
similar mechanism that provides the perception of time in almost every living
organism. Time perception is vital for the healthy functioning of cognitive activities,
physiological needs and behavioral relations, and the bio-psycho-social order's
systematicity. Among the studies conducted, the findings obtained in the studies
related to the effect of psychiatric disorders on the perception of time are somewhat
blurry compared to the others. The research for this study was based on six basic
Polymorphisms known to affect time perception and internal clock mechanisms. These
are as follows: SLC6A4 / 5-HTTLPR, 5HT2A / T102C, DRD2 / TAQ1A, SLC6A3 / 3UTR
VNTR, COMT / VAL158MET, GABRB2 A/C, CLOCK. In our study, the relationship
between the rs1800497 polymorphism, which is one of these seven polymorphisms
that are effective in the functioning of the internal clock in the human brain, and the
inventory used in the measurement of anxiety, was examined in 14 participants. Beck
Anxiety Inventory (BAI) was used to measure anxiety, and PCR was used to detect
genetic variants. When the findings were evaluated, no significant relationship was
found between anxiety and DRD2 rs1800497 polymorphism.
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Keywords
Sağlık Bilimleri, Health Sciences, Klinik Tıp (MED), Clinical Medicine (MED), time perception, internal clock, retrospective time, prospective time, anxiety
Citation
San H. O. , Tarlacı S., Ulucan K., Polat T., Yılmaz Ö. Ö. , Tacal Aslan B., "Investigation of the Relationship between Anxiety Disorder and Time Perception with DRD2 rs1800497 Polymorphism", journal of neurophilosophy, cilt.1, sa.2, ss.171-180, 2022