Person: ÜLGER, NURVER
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ÜLGER
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NURVER
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Publication Open Access A rare Case of otitis media-associated polymicrobial anaerobic meningitis and brain abscess(2021-12-01) ERTÜRK ŞENGEL, BUKET; TİGEN, ELİF; OLUÇ, YUSUF; ÜLGER, NURVER; KORTEN, VOLKAN; ERTÜRK ŞENGEL B., TİGEN E., YILDIZ F., OLUÇ Y., ÜLGER N., KORTEN V.Otitis media-associated complications are widespread when it is not treated with appropriate antimicrobial treatment. Meningitis and brain abscess are the most reported intracranial complications of otitis media, usually caused by the direct spread of organisms from the contagious site. While anaerobic microorganisms are well-known in brain abscesses, they are not common in meningitis. When the clinical history and pathogenesis of otitis mediaassociated meningitis are combined, special methods to identify and cover anaerobic pathogens should be consideredPublication Open Access A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer(ELSEVIER SCI LTD, 2006-08) KARAHASAN, AYŞEGÜL; Toprak, N. Ulger; Yagci, A.; Gulluoglu, B. M.; Akin, M. L.; Demirkalem, P.; Celenk, T.; Soyletir, G.The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.Publication Metadata only The distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites(ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2006) KARAHASAN, AYŞEGÜL; Ulger, N; Rajendram, D; Yagci, A; Gharbia, S; Shah, HN; Gulluoglu, BM; Akin, LM; Demirkalem, P; Celenk, T; Soyletir, GEnterotoxigenic Bacteroides fragilis (ETBF) has been implicated in diarrhoeal illness in animals and humans. Recent data Suggest that ETBF is associated with flares of inflammatory bowel disease. Toxigenicity is attributed to expression of a toxin referred to as fragilysin, which stimulates fluid accumulation in ligated intestinal segments and alter the morphology or human intestinal cells. Three different isoforms or variants of the enterotoxin gene, designated bft-1, bft-2, and bft-3, have been identified. In this study we investigated the distribution of bft alleles among ETBF strains in stool specimens from patients with colon cancer (n:31), the control patients (n: 8) and extraintestinal sources (n: 15). We used restriction fragment length polymorphism analysis of the PCR-amplified enterotoxin gene and sequencing the PCR-product to detect the isoforms of bft gene. Among the stool strains, bft-1 was found to be more common than bft-2; as it was detected 27 of 31 strains from colon cancer patients and 7 of 8 control strains. The bft-1 isoform was also found in almost all isolates from extraintestinal sites. No bft-3 subtype was detected among all tested strains. (C) 2005 Elsevier Ltd. All rights reserved.Publication Metadata only Sağlıklı çocukların orafarenksinde kolonize olan bakteriyel patojenlerin antimikrobiyal duyarlılıkları(Ankara Üniversitesi Tıp Fakültesi Yayınları, 2000-10-11) KARAHASAN, AYŞEGÜL; İLKİ, ZEYNEP ARZU; ÜLGER, NURVER; SÖYLEDİR, GÜNER; Karahasan A., İlki Z. A., Ülger N., Söyledir G.; Cengiz, A. Tevfik; Erdem, Birsel; Dolapçı, G. İştar; Tekeli, F. AlperPublication Open Access Evaluation of direct 16S rRNA PCR from clinical samples for bacterial detection in normally sterile body sites(2019-11-30) ILGIN, CAN; Satilmis, Serife; Ulger Toprak, Nurver; Ilgın, Can; Soyletir, GunerIntroduction: In addition to antibiotic treatment, slow-growing and non-cultivable bacteria can lead to false-negative results for sterile body site infections. In this study, we investigated the efficacy of 16S rRNA polymerase chain reaction (PCR) for such infections. Methodology: Following routine culture procedures, 16S ribosomal RNA (16S rRNA) PCR was performed for samples collected from sterile body sites between July 2017and September 2018. The samples were separated into two groups for likely (group 1) and unlikely infections (group 2) based on clinical and laboratory findings, as well as clinician opinion. Sequence analysis was performed for PCR-positive samples using 16S rRNA primers. Mixed chromatograms were analyzed with the RipSeq Mixed program, and Stata 15.1 was used for statistical analysis. Results: Eighty-seven of 139 samples collected from 116 patients were placed in group 1, and 52 were placed in group 2. Compared with culture as the reference method, the sensitivity, specificity, positive predictive value, and negative predictive value for 16S rRNA PCR were 89.8%, 85.6%, 77.2%, and 93.9%, respectively. 16S rRNA PCR identified infections in 13 culture-negative samples. Among these, three had Bartonella quintana, Mycoplasma salivarium, and Mycobacterium avium complex infections, which cannot be detected with commercial multiplex PCR kits. Conclusions: Our study demonstrates that 16S rRNA PCR is effective for the diagnosis of sterile body site infections, especially for cases of meningitis and infective endocarditis where routine cultures fail.Publication Metadata only Peptoniphilus duerdenii sp nov and Peptoniphilus koenoeneniae sp nov., isolated from human clinical specimens(SOC GENERAL MICROBIOLOGY, 2012) ÜLGER, NURVER; Ulger-Toprak, Nurver; Lawson, Paul A.; Summanen, Paula; O'Neal, Lindsey; Finegold, Sydney M.Two previously uncharacterized strains of Gram-reaction-positive, anaerobic, coccus-shaped bacteria, designated strains WAL 18896(T) and WAL 18898(T), were recovered from human wound specimens and characterized using phenotypic, chemotaxonomic and molecular taxonomic methods. Comparative 16S rRNA gene sequence analysis and chemotaxonomic and biochemical characteristics demonstrated that these organisms are genotypically and phenotypically distinct and represent previously unidentified sublines within the order Clostridiales in the phylum Firmicutes. Pairwise sequence analysis demonstrated that the novel organisms had 91.9% sequence similarity to each other and were most closely related to members of the genus Peptoniphilus. The major long-chain fatty acids of both strains were C-16:0, C-18:0, C-18:1 omega 9C and C-18:2 omega 6,9c. Based on the phenotypic and phylogenetic findings, strains WAL 18896(T) (=CCUG 56065(T) =ATCC BAA-1640(T)) and WAL 18898(T) (=CCUG 56067(T) =ATCC BAA-1638(T) =DSM 22616(T)) represent two novel species, for which the names Peptoniphilus duerdenil sp. nov. and Peptoniphilus koenoeneniae sp. nov. are proposed, respectively.Publication Metadata only Escherichia coli, klebsiella pneumoniae ve Staphylococcus aureus izolatlarında iki yıllık kümülatif antibiyogram sonuçları(2022-11-16) GÜNEŞER, DENİZ; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; ÜLGER, NURVER; KÜÇÜKSU, UĞUR; İLKİ, ZEYNEP ARZU; Güneşer D., Hasdemir Gökboğa M. U., Ülger N., İlki Z. A., Küçüksu U., Ergan B., Akıllı F. M., Sarı ., Demirkol Ö., Demircan S.Giriş ve Amaç: Kümülatif antibiyotik duyarlılık test verileri, bir hastanede belirli bir zaman periyodunda enfeksiyon etkeni bakterilerin tür bazında duyarlılık sonuçlarının incelenmesine imkan sağlayarak o kurumda doğru ampirik tedavi yaklaşımlarının yönlendirilmesinde kilit rol oynamaktadır. Biz burada hastanemizde iki yıllık dönemde Escherichia coli, Klebsiella pneumoniae ve Staphylococcus aureus izolatlarının kümülatif antibiyotik duyarlılık test verilerinin analizini sunuyoruz. Gereç ve Yöntem: Ocak 2020 – Aralık 2021’i kapsayan iki yıllık dönemde hastanemizde erişkin hastalarda enfeksiyon etkeni olduğu belirlenen E. coli, K. pneumoniae, S. aureus izolatlarının yıllık bazda kümülatif antibiyotik test sonuçlarını değerlendirdik. Bu değerlendirmeyi KLİMUD Antibiyotik Duyarlılıklarının Saptanması ve İzlenmesi Çalışma Grubu’nun “Antibiyotik Duyarlılık Verilerinin Analizi Ve Sunumu Rehberi” önerileri doğrultusunda yaptık. Değerlendirmeye, TMC Antibiyotik Duyarlılık Testlerinin Standardizasyonu Çalışma Grubu’nun bakteri türü bazında önerdiği antibiyotikler alındı. Escherichia coli ve K. pneumoniae için değerlendirme idrar ve idrar dışı örnekler (kan, solunum, BOS) bazında, S. aureus için metisilin duyarlılığı bazında yapıldı. Laboratuvarımızda rutin olarak idrar Escherichia coli izolatlarında fosfomisin duyarlılığı disk difüzyon ile, S. aureus’ta metisilin duyarlılığı sefoksitin disk difüzyon ile ve indüklenebilir klindamisin direnci D-test ile belirlenmektedir. İzolatların diğer antibiyotiklere duyarlılıkları ise rutin olarak VITEK2 Compact (bioMérieux, Fransa) otomatize sistemi ile saptanmaktadır. Antibiyotik duyarlılık testlerinin kalite kontrolü laboratuvarımızda rutin olarak haftalık bazda çalışılmaktadır Bulgular ve Sonuç: İki yıllık dönemde, toplam olarak 2958 E. coli, 1690 K. pneumoniae ve 1087 S. aureus kümülatif antibiyograma dahil edildi. Yıllık bazda izolat sayıları Grafik 1, Grafik 2 ve Grafik 3’te gösterilmektedir. Escherichia coli’nin her iki yılda karbapenem, aminoglikozit, fosfomisin ve nitrofurantoin duyarlılıkları %80’in üzerinde saptandı (Grafik 1). Klebsiella pneumoniae’da, idrar dışı izolatların test edilen antibiyotiklere duyarlılıkları idrar izolatlarına kıyasla belirgin olarak düşük saptandı (Grafik 2). 2020 ile 2021 yılları arasında, birkaç antibiyotik dışında (idrar dışı izolatların kinolon ve trimetoprim/sulfametoksazol duyarlılığı) K. pneumoniae izolatlarının duyarlılık yüzdelerinde belirgin bir fark gözlenmedi. Metisilin dirençli S. aureus’ta (MRSA) makrolid, linkozamid ve tetrasiklin duyarlılıkları, metisiline duyarlı S. aureus (MSSA) izolatlarından belirgin olarak düşük bulundu (Grafik 3). Trimetoprim/ sulfametoksazol ve gentamisin duyarlılıkları açısından, MRSA ve MSSA izolatları açısından belirgin bir fark saptanmadı. Beklenildiği üzere, glikopeptit direnci hiçbir izolatta saptanmadı. Sadece bir izolatta saptanan linezolid direnci doğrulandı. Pandemi döneminPublication Metadata only Hastanemizden Bir Non Toksijenik {Vibrio cholerae} Bakteriyemi Olgusu(2022-11-16) İLKİ, ZEYNEP ARZU; ODABAŞI, ZEKAVER; ÜLGER, NURVER; Ergan B., Kökkaya Y. E., Levent B., Çağlayık D. Y., İlki Z. A., Odabaşı Z., Ülger N.Publication Metadata only Asymtomatic carriage of Neisseria meningitidis and Neisseria lactamica in relation to Streptococcus pneumoniae and Haemophilus influenzae colonization in healthy children: apropos of 1400 children sampled(2001) KARAHASAN, AYŞEGÜL; Bakir, M.; Yagci, A.; Ulger, N.; Akbenlioglu, C.; Ilki, A.; Soyletir, G.Meningococcal disease is one of the most important causes of morbidity and mortality among children in many parts of the world. Main reservoir of carriage and site of meningococcal dissemination appears to be the upper respiratory tract. Colonization of Neisseria meningitidis and lactamica and factors affecting this carriage were determined in a group of healthy children aged 0-10 years. Meningococcus and N. lactamica carriage were detected in 17 (1.23%) and 245 (17.7%) of 1382 subjects, respectively. Number (%) of serogroups for meningococci was 1 (6), 5 (29), 0 (0), 1 (6), 1 (6), and 9 (53) for A, B, C, D, W135, and Y, respectively. Having more than three household members, elementary school attendance, pharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae were associated with carriage of meningococci, whereas age less than 24-month was associated with carriage of N. lactamica. There was a reverse carriage rate between N. meningitidis and N. lactamica by age which may suggest a possible protective role of N. lactamica against meningococcal colonization among pre-school children.Publication Metadata only The role of human bocavirus on respiratory tract infections in children(2023-05-08) İLKİ, ZEYNEP ARZU; ÜLGER, NURVER; KEPENEKLİ KADAYİFCİ, EDA; Aslan Tuncay S., Ergan B., Ergenç Z., Yılmaz S., Parlak B., Canizci Erdem P., Dizi Işık A., İlki Z. A., Ülger N., Kepenekli Kadayifci E.