Person: YOLDEMİR, AHMET TEVFİK
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YOLDEMİR
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AHMET TEVFİK
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Publication Metadata only Importance of genitourinary syndrome of menopause in the quality of life of postmenopausal women(2022-10-27) YOLDEMİR, AHMET TEVFİK; Çevik C. E. , Yoldemir A. T.Publication Metadata only Tıbbi müdahalelerde uzmanlık vetki sinirinin değerlendirilmesi: olgu sunumu(2022-11-06) YOLDEMİR, AHMET TEVFİK; Ertaş O. C. , Kalem Y., Yoldemir A. T. , Arıcan N.Publication Metadata only Relation between hot flushes and endothelial dysfunction in postmenopausal women(2021-10-10) YOLDEMİR, AHMET TEVFİK; Çevik C. E., Yoldemir A. T.Objective: To evaluate the relation between hot flushes and endothelial dysfunction in postmenopausal women: Study Design: A study was conducted on total of 132 women, who are between 45-65 years old and applied to Marmara University Pendik Research and Teaching Hospital Outpatient Clinic of Gynaecology, of whom 79 were postmenopausal women and 53 were premenopausal women. Of 132 participants, 32 experience no flushes, 22 mild, 40 moderate, and 38 severe. The demographic, metabolic, and hormonal characteristics were noted and all of the subjects completed within the duration of one week three-category hot flush diary that was conformed to FDA and EMEA guidelines, out of which none, mild, moderate, and severe groups were obtained. Carotid Intima Media Thickness (CIMT) and Flow Mediated Dilatation (FMD) on Brachial Artery measurements were completed on each one of the subject. A prospective case control study was performed. Only 76 Women agreed their blood to be drawn. Results: Mean FMD and CIMT values were similar in premenopausal and postmenopausal women (p=0.06). Blood biochemical values were similar in premenopausal and postmenopausal women. Mean FMD and CIMT values were similar both in the absence and the presence of the hot flushes, regardless of their severity. There was a direct correlation between the presence of the hot flushes, regardless of their severity and the time elapsed since menopause (p=0.001). Mean CIMT, FMD, blood biochemical values were similar both in the absence and the presence of the hot flushes, regardless of their severity. Conclusion: Direct correlation between the severity of hot flushes and the endothelial dysfucntion in postmenopausal was not found. There was a direct correlation between the presence of the hot flushes, regardless of their severity and the time elapsed since menopause (p=0.001).Publication Metadata only Uterine ageing(2023-05-04) YOLDEMİR, AHMET TEVFİK; Yoldemir A. T.Studies using animal models, have investigated the influence of increasing age on uterine factors that might lead to abnormal decidualization and reduced implantation and defective placentation. The decidual response to a standardized estrogen /progesterone stimulus was reduced in the older animals; whereas, in young rodents decidual response closely resembled the normal decidual response during implantation. Furthermore in rodents, there was a decrease in the expression of endometrial estrogen and progesterone receptor in older ones. Several microRNAs have been associated with the fibrosis process in mice causing age-related uterine dysfunction. Aging of the uteri lead to the downregulation of several genes associated with cell proliferation in mice, indicating impaired proliferation in the presence of senescent cells.In vitro studies of human endometrial stromal cell proliferation revealed that presence of senescent endometrial stromal cells within the endometrium, as well as senescence-associated secretory phenotype secretion which could disturb normal functional activities such as communication with epithelial and endothelial cells, glands formation, vascularization and immune cells attraction. Human endometrial gene expression studies showed that some gene expressions increased as others decreased with age. Likewise some endometrium functions were either up-regulated or down-regulated after 35 years of age. Similarly some ciliary processes were significantly up-regulated in the endometrium of older women (40 years) while some functions associated with cell cycle/ proliferation were down-regulated.The progesterone-governed endometrial transformation is necessary for implantation. Studies which investigated the influence of endometrial ageing on reproductive outcomes in oocyte donation cycles have controversial results. Some authors showed no influence whereas others reported the age-related decline in implantation and pregnancy rates using euploid embryos or young oocyte donors. Lower implantation and live birth rates with fresh donor oocytes for women over 44 years of age were reported when compared to younger recipients. High doses of progesterone could compensate for the abnormal receptivity of aged recipients during oocyte donation. Moreover maternal age over 40 years was associated with a further increase in risk for placental abruption, preterm delivery, low birthweight, intrauterine growth restriction, stillbirth, and perinatal mortality.Publication Metadata only Çözüm ultra düşük doz hormon tedavisi: Gerçekten etkin ve güvenli mi(Nobel Tıp Kitapevi, 2013-12-01) YOLDEMİR, AHMET TEVFİK; Yoldemir A. T.Publication Metadata only Diagnosis and management of endometriosis(2022-10-27) YOLDEMİR, AHMET TEVFİK; Yoldemir A. T.Publication Metadata only Yapay zeka ve uygulamalar(2022-10-23) YOLDEMİR, AHMET TEVFİK; Yoldemir A. T.