Publication: Relation between hot flushes and endothelial dysfunction in postmenopausal women
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Date
2021-10-10
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Abstract
Objective: To evaluate the relation between hot flushes and endothelial dysfunction in postmenopausal women:
Study Design: A study was conducted on total of 132 women, who
are between 45-65 years old and applied to Marmara University Pendik
Research and Teaching Hospital Outpatient Clinic of Gynaecology, of
whom 79 were postmenopausal women and 53 were premenopausal
women. Of 132 participants, 32 experience no flushes, 22 mild, 40 moderate, and 38 severe. The demographic, metabolic, and hormonal characteristics were noted and all of the subjects completed within the duration of one week three-category hot flush diary that was conformed
to FDA and EMEA guidelines, out of which none, mild, moderate, and
severe groups were obtained. Carotid Intima Media Thickness (CIMT)
and Flow Mediated Dilatation (FMD) on Brachial Artery measurements
were completed on each one of the subject. A prospective case control
study was performed. Only 76 Women agreed their blood to be drawn.
Results: Mean FMD and CIMT values were similar in premenopausal
and postmenopausal women (p=0.06). Blood biochemical values were
similar in premenopausal and postmenopausal women. Mean FMD and
CIMT values were similar both in the absence and the presence of the
hot flushes, regardless of their severity. There was a direct correlation
between the presence of the hot flushes, regardless of their severity and
the time elapsed since menopause (p=0.001). Mean CIMT, FMD, blood
biochemical values were similar both in the absence and the presence
of the hot flushes, regardless of their severity.
Conclusion: Direct correlation between the severity of hot flushes
and the endothelial dysfucntion in postmenopausal was not found. There
was a direct correlation between the presence of the hot flushes, regardless of their severity and the time elapsed since menopause (p=0.001).
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Sağlık Bilimleri, Health Sciences, Klinik Tıp (MED), Clinical Medicine (MED)
Citation
Çevik C. E., Yoldemir A. T., \"Relation between hot flushes and endothelial dysfunction in postmenopausal women\", 13th European Congress on Menopause and Andropause, Berlin, Almanya, 8 - 10 Eylül 2021, cilt.152, ss.78-79