Person: TOKER, AYŞE EBRU
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TOKER
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AYŞE EBRU
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Publication Metadata only Isolated bilateral optic neuropathy in acute disseminated encephalomyelitis(SLACK INC, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Yilmaz, YPublication Metadata only Influence of serum levels of sex hormones on intraocular pressure in menopausal women(LIPPINCOTT WILLIAMS & WILKINS, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Temel, APurpose: The purpose of this study was to assess the effect that changes in sex hormone levels have on intraocular pressure (IOP) in menopausal women. Subjects and Methods: Thirty menopausal women on hormone replacement therapy and 32 menopausal women who had never received hormone replacement therapy (HRT), matched for age and duration of amenorrhea, participated in this study. Intraocular pressures were measured with Goldmann applanation tonometer. Serum levels were measured for estradiol, free testosterone, and follicle stimulating hormone (FSH). The influence of serum hormone levels on IOP was assessed by correlation analysis. Results: The mean IOP of postmenopausal women receiving HRT (13.29 +/- 2.28 mm Hg) was not significantly different from that of menopausal women not receiving HRT (13.56 +/- 2.5 min Hg, P = 0.24). Higher testosterone levels were associated with higher IOPs in women receiving HRT (r = 0.48, P = 0.02) and in those not receiving HRT (r = 0.42, P = 0.003). No significant correlations were observed between IOP and serum levels of estradiol and FSH in either group. Conclusion: Our data provide evidence for a relation between serum testosterone levels and IOP in menopause. Higher testosterone seems to have a tendency to increase IOP in menopausal women.Publication Metadata only Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis(SAGE PUBLICATIONS LTD, 2003) TOKER, AYŞE EBRU; Acar, N; Toker, E; Kazokoglu, HPURPOSE. Eosinophil cationic protein (ECP) levels in tear fluid and sera of patients with seasonal allergic conjunctivitis (SAC) were measured to assess local and systemic eosinophilic activity in SAC. The correlation between ECP levels and disease activity was evaluated. METHODS. Tears and sera were collected from 21 patients with SAC and 13 healthy control subjects. ECP levels in tears and sera were measured before and 4 weeks after treatment with 0.1% lodoxamide eyedrops. Clinical signs and symptoms of SAC were scored and the correlation of ECP levels with the clinical scores was evaluated. RESULTS. Tear and serum levels of ECP were significantly increased (p=0.01, p=0.02, respectively) in patients with SAC compared with the control subjects, but ECP levels were not correlated with the severity of the disease. Following treatment with topical 0.1% lodoxamide eyedrops, the mean level of ECP in tears decreased significantly (p=0.02), whereas no significant change was observed in serum ECP levels. Furthermore, a significant decrease in clinical signs and symptoms scores was found after treatment (both p<0.0001). CONCLUSIONS. Increased serum and tear ECP levels in patients with SAC confirms that both local and systemic eosinophil activation occurs in SAC, However, clinical signs and symptoms of SAC were not found to be correlated with the degree of eosinophilic activity. Thus ECP does not seem to have an important role in clinical manifestations of SAC.Publication Open Access The influence of sex hormones on ocular blood flow in women(WILEY, 2003-12) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Akpinar, I; Aribal, E; Kazokoglu, HPurpose: To investigate the influence of sex hormones on ocular haemodynamics, blood flow velocities in the ophthalmic and central retinal arteries and serum levels of sex hormones were measured in pre- and postmenopausal women. Methods: Colour Doppler imaging (CDI) was used to determine the flow velocities (peak systolic velocity [PSV] and end-diastolic velocity [EDV]) and the resistive index (RI) in the ophthalmic and central retinal arteries in 22 premenopausal and 32 postmenopausal women, who had never received hormone replacement therapy. Serum levels were measured for oestradiol, free testosterone and follicle-stimulating hormone. The CDI parameters were compared between the two groups and the influence of serum levels of oestradiol and testosterone on blood flow velocities and the resistive indices were analysed. Results: After correcting for age and mean arterial blood pressure, an analysis of covariance disclosed a significantly lower EDV (p = 0.02) and a significantly higher RI (p = 0.01) in the central retinal artery of postmenopausal women compared with premenopausal women. Partial correlation analysis, controlling for age, revealed significant correlations between the CDI parameters and serum levels of oestradiol and testosterone. For premenopausal women, PSV (r = 0.58, p = 0.04) and EDV (r = 0.73, p = 0.006) in the ophthalmic artery correlated positively with serum oestradiol levels. The RI in the central retinal artery decreased with increasing oestradiol levels in both groups (premenopausal r = - 0.40, p = 0.04; postmenopausal r = - 0.32, p = 0.05). Peak systolic velocity in the central retinal artery correlated negatively (r = - 0.49, p = 0.04), whereas the RI correlated positively (r = 0.53, p = 0.02) with testosterone levels in the premenopausal group. Postmenopausal women with higher testosterone levels had lower EDV (r = - 0.53, p = 0.007) in the central retinal artery and higher RI in both vessels (ophthalmic artery r = 0.48, p = 0.01; central retinal artery r = 0.61, p = 0.002). Conclusion: Our data provide evidence of a relationship between serum sex hormone levels and blood flow velocities and resistive indices in retrobulbar arteries. Oestradiol appears to have beneficial effects on ocular haemodynamics, whereas testosterone may act as an antagonistic to the effects of oestrogen.Publication Open Access High dose intravenous steroid therapy for severe posterior segment uveitis in Behcet's disease(BMJ PUBLISHING GROUP, 2002-05-01) TOKER, AYŞE EBRU; Toker, E; Kazokoglu, H; Acar, NAim: To evaluate the safety and effectiveness of high dose intravenous steroid therapy (HDIST) in Behcet's disease patients with severe posterior segment uveitis attacks. Methods: Five patients with ocular Behcet's disease were treated with HDIST for severe posterior segment attacks. Two patients had vasculitis, one patient had papillitis, and the other two had retinitis; four patients also had accompanying severe vitritis. The visual acuities and improvement in ocular signs after HDIST were evaluated, Results: During HDIST, patients had no systemic complications caused by treatment, All patients responded to HDIST with evidence of a decrease in intraocular inflammatory activity and improved visual acuities within a mean time of 7 (1-15) days of commencing treatment. During follow up three out of five patients had new posterior segment attacks. Conclusion: HDIST is effective in controlling severe, vision threatening acute posterior segment Behcet's uveitis attacks and in improving visual function in a short period of time.Publication Open Access To report a case of crystalline keratopathy induced by Dieffenbachia plant sap and literature review(2022-03-01) BAĞATUR VURGUN, ELİF; ARSLAN, SILA CANSU; TOKER, AYŞE EBRU; Akkaya Turhan, Semra; Bagatur Vurgun E., Arslan S. C., Turhan S. A., TOKER A. E.© 2022 The AuthorsPurpose: To report a case of crystalline keratopathy induced the Dieffenbachia plant sap. Methods: Case report and review of the literature. Results: A 38-year-old woman presented with redness, irritation, and slightly blurred vision in the right eye after the exposure of Dieffenbachia plant sap to her right eye. The patient\"s eye was irrigated with copious saline on her admission. On ophthalmic examination, her visual acuity was 20/32 OD and 20/20 OS. Anterior segment examination of the right eye revealed mild eyelid edema, grade 2 conjunctival hyperemia, diffuse punctate corneal epithelial erosions, mild stromal edema, and fine refractile needle-like crystals extending from the subepithelial region to mid-stroma. The crystals were visualized with anterior segment photographs and in vivo corneal confocal microscopy (IVCCM) views. Moxifloxacin 0.5% and preservative-free artificial tears were started. Loteprednol etabonate 0.5% was added once the epithelial erosions had healed. The corneal crystals were completely disappeared and the visual acuity of the patient was 20/20 in the third week\"s visit. Conclusions: Patients with a history of contact with plant sap should be irrigated with abundant saline immediately to reduce the effect of chemical trauma and thus reduce mechanical damage by inhibiting crystal penetration. IVCCM offers a non-invasive, fast, and reliable diagnosis of Dieffenbachia-related injury, especially in patients with ocular irritation of unknown etiology. Besides, IVCCM is very valuable to differentiate calcium oxalate crystals from other crystalline corneopathies.Publication Metadata only Colobomatous macrophthalmia with microcornea syndrome maps to the 2p23-p16 region(WILEY-LISS, 2007) TOKER, AYŞE EBRU; Elcioglu, Nursel H.; Akin, Burcu; Toker, Ebru; Elcioglu, Mustafa; Kaya, Ali; Tuncali, Timur; Wollnik, Bernd; Hornby, Steha; Akarsu, Nurten A.Colobomatous macrophthalmia with microcornea syndrome (OMIM 602499) is a rare, autosomal dominant malformation characterized by microcornea, uveal coloboma, axial enlargement of the globe, and myopia. Using what is currently the largest described pedigree and candidate localization approach, we first excluded the candidate genes PAX2, PAX3, PAX6, and PAX9. Subsequently, the chromosome 14q24 region containing the CHX10, SIX1, and SIX4 genes were also excluded. Positive LOD scores were obtained with the DNA markers selected from the 2p23-p16 region. A maximum pail-wise LOD score of 3.61 (Theta = 0) was noted with the DNA marker D2S1788. Haplotype analysis positioned the locus between DNA markers D2S2203 and D2S1352 within a 22 Mb physical interval. This region contains major candidate genes, such as SIX2, SIX3, and CYP1B1; however, mutation analysis did not identify a Causative Mutation in these genes. Macrophthalmia, colobomatous, with microcornea (MACOM) is proposed as the gene symbol for this malformation linked to 2p23-p16. (c) 2007 Wiley-Liss, Inc.Publication Metadata only Recurrence After Primary Pterygium Excision: Amniotic Membrane Transplantation with Fibrin Glue Versus Conjunctival Autograft with Fibrin Glue(TAYLOR & FRANCIS INC, 2016) TOKER, AYŞE EBRU; Toker, Ebru; Eraslan, MuhsinPurpose: The aim of the present study was to compare the surgical results and recurrence rates of primary pterygium excision with conjunctival autografts versus amniotic membrane grafts fixated with fibrin glue.Materials and methods: In this prospective study, 73 eyes of 65 patients who had undergone conjunctival autograft group (CAG) (n:37) or amniotic membrane group (AMG) (n:36) after pterygium excision were evaluated. Fibrin glue was used for the fixation of grafts in both groups. The patients were followed up for 12 months. Postoperative complications were recorded. The rate of recurrence was defined as the primary outcome measure.Results: In the CAG, partial dehiscence of the graft was observed on the nasal edge on postoperative day 1 in two (5.4%) eyes that healed with secondary re-epithelialization at week 1. Twelve (32.4%) eyes showed a yellowish-orange or hemorrhagic edema of the graft on postoperative day 7 that spontaneously resolved in 1 to 3 weeks. In the AMG, partial dehiscence and folding of the amniotic membrane occurred in two (5.5%) eyes. Two eyes (5.4 %) in the CAG developed corneal recurrence and five eyes (13.8%) in the amniotic membrane graft group developed recurrence; one limbal (2.7%), four corneal recurrences (11.1%) (p=0.25).Conclusion: Fibrin glue is a safe and effective method for attaching conjunctival or amniotic membrane grafts for wound closure following pterygium surgery. Although the results were not statistically significant, amniotic membrane grafting using fibrin glue seems to have a higher pterygium recurrence rate compared with conjunctival autografting.Publication Open Access Clinical Performance of Samfilcon A Contact Lenses in Intensive Digital Device Users: A Multicenter, Prospective Clinical Study(2021-12) TOKER, AYŞE EBRU; Uçakhan, Ömür Ö.; Taşındı, Emrullah; Toker, Ebru; Çiftçi, Ferda; Kurna, Sevda Aydın; Acar, Mutlu; Özçelik, Ferah; Çelebi, Ali Rıza Cenk; Yıldız, Hatice Elvin; Akova, Yonca Aydın; Öncü, Emine Sibel; Özbek, Zeynep; Tuncer, Zerrin; Kocabeyoğlu, Sibel; Şeker, Burak; Kaya, Deniz; Barakat, MaximePublication Metadata only Psychiatric morbidity of patients with keratoconus: A cross-sectional study(PERGAMON-ELSEVIER SCIENCE LTD, 2021) TOKER, AYŞE EBRU; Yildiz, Mesut; Turhan, Semra Akkaya; Yargi, Berru; Ergun, Serhat; Ornek, Erdem; Baz, Fatih; Toker, Ayse EbruBackground: This study aimed to determine the prevalence of psychiatric disorders in patients with keratoconus and the effect of clinical parameters and psychiatric morbidity on quality of life in this patient group. Materials and methods: This cross-sectional study enrolled 94 patients with keratoconus. All patients underwent a complete ophthalmic and psychiatric examination and completed the The National Eye Institute Refractive Error Quality of Life Instrument-42 (NEI-RQL-42), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) questionnaires. The current diagnosis of psychiatric disorders was determined using the Structured Clinical Interview for DSM-IV (SCID). The impact of disease severity (binocular BCVA >0.4 logMAR, steep K reading >52, and Amsler-Krumeich grades) on vision-related quality of life was also analyzed. Results: The patients? mean age was 23.9 ? 4.8 (range, 18?40) years. Of the 94 participants 35 (37.2%) had a psychiatric diagnosis, 13 (13.8%) had moderate-severe depression and 20 (21.2%) had moderate-severe anxiety according to the BDI and BAI, respectively. The probability of having a psychiatric disorder was higher if the keratoconus was more severe. Patients with a psychiatric diagnosis scored lower on physical functioning, role limitations due to emotional problems, energy/fatigue; emotional well-being, social functioning and pain subscales of the Short Form-36 (SF-36). Having a SCID-1 psychiatric diagnosis and the presence of a psychiatric disorder did not significantly affect NEI-RQL-42 questionnaire scores. Conclusions: There was high psychiatric morbidity among patients with keratoconus. Having a psychiatric disorder was associated with lower QoL as measured using the SF-36.