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The effect of Momordica charantia intake on the estrogen receptors ESR alpha/ESR beta gene levels and apoptosis on uterine tissue in ovariectomy rats

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dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsCevik, Ozge; Akpinar, Hikmet; Oba, Rabia; Cilingir, Ozlem Tugce; Ozdemir, Zarife Nigar; Cetinel, Sule; Yoldemir, Tevfik
dc.date.accessioned2022-03-13T12:50:21Z
dc.date.available2022-03-13T12:50:21Z
dc.date.issued2015
dc.description.abstractEstrogen or combinational hormone therapy can protect to menopausal symptoms but exogenous estrogen therapy has some potential risks which in turns lead to the appearance of various diseases. In recent years plants with high phytoestrogen content are recommended as therapeutic agents for postmenopausal hormonal treatment. In this research, we investigated the effects of Momordica charantia (MC) on the estrogen production and E2 as well as anti-oxidative and anti-apoptotic role on the ovariectomy rat model. The rats were ovariectomized and fed on 2 g/kg of fruit extra of MC for 30 days by gavage. 17-beta estradiol (E2) and 8-OHdG levels in serum, markers of oxidative damage of ROS and ESR alpha, ESR beta and NF-kB gene levels were measured in uterus horn tissue. Caspase-3, caspase-9, TNF-alpha, IL-6, IL-10, Bcl-2 and Nf-kB proteins expression were assessed by western blotting. Structural changes in tissue were examined with H&E staining. MC administration also stimulated the E2 production and ESR alpha/ESR beta gene levels and the inhibited oxidative damage. Furthermore, MC treatment enhanced anti-apoptotic and anti-inflammatory process and tissue regeneration. Data herein support that MC directly regulates uterine estrogen response and may serve as a new phytoestrogenic substance for the treatment of post-menopausal symptoms.
dc.identifier.doi10.1007/s11033-014-3756-7
dc.identifier.eissn1573-4978
dc.identifier.issn0301-4851
dc.identifier.pubmed25253099
dc.identifier.urihttps://hdl.handle.net/11424/238364
dc.identifier.wosWOS:000349006400018
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofMOLECULAR BIOLOGY REPORTS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMomordica charantia
dc.subjectOverectomy
dc.subject17-beta Estradiol
dc.subjectEstrogen receptors
dc.subjectOxidative DNA damage
dc.subjectApoptosis
dc.subjectOXIDATIVE DAMAGE
dc.subjectER-ALPHA
dc.subjectANTIOXIDANT
dc.subjectMECHANISMS
dc.subjectEXTRACT
dc.subjectPREVENTION
dc.subjectPHYTOESTROGENS
dc.subjectPROGESTERONE
dc.subjectEXPRESSION
dc.subjectLEIOMYOMA
dc.titleThe effect of Momordica charantia intake on the estrogen receptors ESR alpha/ESR beta gene levels and apoptosis on uterine tissue in ovariectomy rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id6c602330-6c61-473e-8aa7-880e4583ed0e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages11
oaire.citation.endPage177
oaire.citation.issue1
oaire.citation.startPage167
oaire.citation.titleMOLECULAR BIOLOGY REPORTS
oaire.citation.volume42
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

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