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Propylthiouracil-induced hypothyroidism protects ionizing radiation-induced multiple organ damage in rats

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsSener, G.; Kabasakal, L.; Atasoy, B. M.; Erzik, C.; Velioglu-Ogunc, A.; Cetinel, S.; Contuk, G.; Gedik, N.; Yegen, B. C.
dc.date.accessioned2022-03-14T09:57:34Z
dc.date.available2022-03-14T09:57:34Z
dc.date.issued2006-05
dc.description.abstractThe objective of this study was to examine the potential radioprotective properties of propylthiouracil (PTU)-induced hypothyroidism against oxidative organ damage induced by irradiation. Sprague-Dawley rats were pre-treated with saline or PTU (10 mg/kg i.p.) for 15 days, and were then exposed to whole-body irradiation (800 cGy). A group of rats were decapitated at 6 h after exposure to irradiation, while another group was followed for 72 h after irradiation, during which saline or PTU injections were repeated once daily. Lung, liver, kidney and ileum samples were obtained for the determination of malondialdehyde (MDA; an index of lipid peroxidation) and glutathione (GSH, an antioxidant) levels, myeloperoxidase activity (MPO; an index of tissue neutrophil accumulation) and collagen contents, while oxidant-induced DNA fragmentation was evaluated in the ileal tissues. All tissues were also examined microscopically and assayed for the production of reactive oxidants using chemiluminescence (CL). Lactate dehydrogenase (LDH), an indicator of tissue damage, and turnout necrosis factor-alpha (TNF alpha) were assayed in serum samples. Irradiation caused a significant decrease in GSH level, which was accompanied by significant increases in MDA levels, MPO activity, CL levels and collagen content of the tissues studied (P < 0.05-0.001). Similarly, serum TNFa and LDH were elevated in the irradiated rats as compared with the control group. On the other hand, PTU treatment reversed all these biochemical indices, as well as histopathological alterations induced by irradiation. Our results suggested that PTU-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms.
dc.identifier.doi10.1677/joe.1.06574
dc.identifier.eissn1479-6805
dc.identifier.issn0022-0795
dc.identifier.pubmed16648293
dc.identifier.urihttps://hdl.handle.net/11424/243769
dc.identifier.wosWOS:000237730900007
dc.language.isoeng
dc.publisherBIOSCIENTIFICA LTD
dc.relation.ispartofJOURNAL OF ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectINDUCED OXIDATIVE STRESS
dc.subjectLIPID-PEROXIDATION
dc.subjectLIVER-MITOCHONDRIA
dc.subjectANTITHYROID DRUGS
dc.subjectREACTIVE OXYGEN
dc.subjectTHYROID STATUS
dc.subjectINJURY
dc.subjectMYELOPEROXIDASE
dc.subjectHYPERTHYROIDISM
dc.subjectDYSFUNCTION
dc.titlePropylthiouracil-induced hypothyroidism protects ionizing radiation-induced multiple organ damage in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id0baadf3f-b9c0-4603-8bd0-778113eea808
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages13
oaire.citation.endPage269
oaire.citation.issue2
oaire.citation.startPage257
oaire.citation.titleJOURNAL OF ENDOCRINOLOGY
oaire.citation.volume189
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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