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Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsAgrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, Leyla
dc.date.accessioned2022-03-14T09:04:02Z
dc.date.available2022-03-14T09:04:02Z
dc.date.issued2018-06-28
dc.description.abstractHyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.
dc.identifier.doi10.1155/2018/3874131
dc.identifier.eissn2314-6141
dc.identifier.issn2314-6133
dc.identifier.pubmed30050929
dc.identifier.urihttps://hdl.handle.net/11424/242355
dc.identifier.wosWOS:000437481100001
dc.language.isoeng
dc.publisherHINDAWI LTD
dc.relation.ispartofBIOMED RESEARCH INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMOLECULAR-WEIGHT
dc.subjectIN-VITRO
dc.subjectDELIVERY
dc.subjectDEGRADATION
dc.subjectHYDROGELS
dc.subjectMARROW
dc.subjectPROLIFERATION
dc.subjectAUGMENTATION
dc.subjectEXPRESSION
dc.subjectIMPLANTS
dc.titleEvaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects
dc.typearticle
dspace.entity.typePublication
local.avesis.id01f7ab0f-007b-4c0d-b93a-bb364450699e
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber3874131
local.journal.numberofpages8
local.journal.quartileQ3
oaire.citation.titleBIOMED RESEARCH INTERNATIONAL
oaire.citation.volume2018
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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