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Henoch-Schonlein Nephritis: A Nationwide Study

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dc.contributor.authorALPAY, HARİKA
dc.contributor.authorsSoylemezoglu, O.; Ozkaya, O.; Ozen, S.; Bakkaloglu, A.; Dusunsel, R.; Peru, H.; Cetinyurek, A.; Yildiz, N.; Donmez, O.; Buyan, N.; Mir, S.; Arisoy, N.; Gur-Guven, A.; Alpay, H.; Ekim, M.; Aksu, N.; Soylu, A.; Gok, F.; Poyrazoglu, H.; Sonmez, F.
dc.date.accessioned2022-03-12T16:01:22Z
dc.date.available2022-03-12T16:01:22Z
dc.date.issued2009
dc.description.abstractBackground/Aim: The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schonlein purpura (HSP) nephritis in children. Methods: Clinical and laboratory data of 443 children with HSP nephritis aged between 3 and 16 years from 16 pediatric nephrology reference centers were analyzed retrospectively. The biopsy findings were graded according to the classification developed by the International Study of Kidney Disease in Children (ISKDC). Results: Renal biopsy was performed in 179 of the patients with HSP nephritis. The most common presenting clinical finding in patients who were biopsied was nephrotic range proteinuria (25%) which was followed by nephritic-nephrotic syndrome (23.5%). The biopsy findings according to the ISKDC were as follows: class I: 8.3%; II: 44.1%; III: 36.3%; IV: 6.7%; V: 3.3%; VI: 1.1%. All of the patients who developed end-stage renal disease had nephritic-nephrotic syndrome at presentation. Of 443 patients, 87.2% had a favorable outcome and 12.8% had an unfavorable outcome. The overall percentage of children who developed end-stage renal disease at follow-up was 1.1%. Logistic regression analysis did not show any association of initial symptoms and histology with outcome. Conclusion: In the presented cohort, the presence of crescents in the first biopsy or presenting clinical findings did not seem to predict the outcome of HSP nephritis in children. We conclude that children with HSP nephritis even with isolated microscopic hematuria and/or mild proteinuria should be followed closely. Copyright (C) 2009 S. Karger AG, Basel
dc.identifier.doi10.1159/000218109
dc.identifier.issn1660-2110
dc.identifier.pubmed19439991
dc.identifier.urihttps://hdl.handle.net/11424/224849
dc.identifier.wosWOS:000266882400012
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofNEPHRON CLINICAL PRACTICE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChildren
dc.subjectHenoch-Schonlein purpura
dc.subjectNephritis
dc.subjectOutcome
dc.subjectTreatment
dc.subjectLONG-TERM PROGNOSIS
dc.subjectPURPURA NEPHRITIS
dc.subjectCHILDREN
dc.subjectTHERAPY
dc.subjectCLASSIFICATION
dc.subjectDISEASE
dc.titleHenoch-Schonlein Nephritis: A Nationwide Study
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.id371bd667-7a5c-4b58-944e-646e4fe83cef
local.conference.dateSEP 10-13, 2005
local.conference.locationIstanbul, TURKEY
local.conference.sponsorEuropean Soc Paediat Nephrol
local.conference.title39th Annual Meeting of the European-Society-for-Paediatric-Nephrology
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPageC204
oaire.citation.issue3
oaire.citation.startPageC199
oaire.citation.titleNEPHRON CLINICAL PRACTICE
oaire.citation.volume112
relation.isAuthorOfPublication102b331c-4c62-4795-880d-234f6b72fa6a
relation.isAuthorOfPublication.latestForDiscovery102b331c-4c62-4795-880d-234f6b72fa6a

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