Publication:
Increased QT dispersion in epileptic children

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dc.contributor.authorAKALIN, FİGEN
dc.contributor.authorsAkalin, F; Tirtir, A; Yilmaz, Y
dc.date.accessioned2022-03-12T17:16:26Z
dc.date.available2022-03-12T17:16:26Z
dc.date.issued2003
dc.description.abstractAim: Epilepsy is a common paroxysmal disorder in childhood. Tachyarrhythmia, bradyarrhythmia, asystole, atrioventricular block, ventricular fibrillation or sudden death may occur during seizures. Mutations of ion-channel coding genes are found in patients with idiopathic or cryptogenic epilepsy. The ion channels also play a role in arrhythmogenesis. QT dispersion is a non-invasive method for assessment of regional repolarization differences within the myocardial tissue. This study investigated QT and QTc dispersion (QTcd) and the risk of dysrhythmia in epileptic children. Methods: The first group included 28 patients with newly diagnosed epilepsy and not taking antiepileptic treatment (range 10 mo to 15 y, mean+/-SD 6.86+/-3.92 y), the second group included 34 patients taking antiepileptic treatment (range 1-14 y, mean+/-SD 7.51+/-3.68 y) and the control group included 52 healthy children (range 4 mo to 15 y, mean+/-SD 6.94+/-3.92 y). Twelve-lead ECGs were obtained and heart rate, RR interval, P wave amplitude and duration, PR interval, QRS duration, QRS axis and QT intervals were measured, and QTc, QTd, QTcd were calculated in all subjects. The measurements were repeated in the first group under antiepileptic treatment. Results: While no significant difference in terms of heart rate, RR interval, P wave amplitude and duration, PR interval, QRS duration, QRS axis, QT intervals or QTc intervals was found, QTd and QTcd values were significantly increased in epileptic children compared with,the control group. QTd was 58.1+/-13.4 ms and 35.9+/-9.3 ms and QTcd was 91.0+/-22.9 and 68.6+/-18.0 ms in patients and controls, respectively. Antiepileptic treatment did not affect QT dispersion. Conclusion: QT dispersion is increased in epileptic children. Further investigation is needed to reveal the pathogenesis of myocardial repolarization abnormalities in epileptic patients.
dc.identifier.doi10.1080/08035250310003550
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.pubmed12948066
dc.identifier.urihttps://hdl.handle.net/11424/227570
dc.identifier.wosWOS:000184808300007
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofACTA PAEDIATRICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdysrhythmia
dc.subjectepilepsy
dc.subjection channels
dc.subjectQT dispersion
dc.subjectventricular repolarization
dc.subjectLONG QT
dc.subjectION CHANNELS
dc.subjectSEIZURES
dc.subjectDEATH
dc.subjectABNORMALITIES
dc.subjectEPILEPSIES
dc.subjectDISORDERS
dc.subjectINTERVAL
dc.subjectMOUSE
dc.subjectBRAIN
dc.titleIncreased QT dispersion in epileptic children
dc.typearticle
dspace.entity.typePublication
local.avesis.id5f1f927c-106d-4eb0-b4f6-5a1ae70aa5e0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage920
oaire.citation.issue8
oaire.citation.startPage916
oaire.citation.titleACTA PAEDIATRICA
oaire.citation.volume92
relation.isAuthorOfPublication17626f9a-f783-4597-8684-38b4a8765e94
relation.isAuthorOfPublication.latestForDiscovery17626f9a-f783-4597-8684-38b4a8765e94

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