Publication:
Severity of Depression and Anxiety Symptoms is Associated with Increased Arterial Stiffness in Depressive Disorder Patients Undergoing Psychiatric Treatment

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dc.contributor.authorSARI, İBRAHİM
dc.contributor.authorsYanartas, Omer; Sunbul, Murat; Durmus, Erdal; Kivrak, Tarik; Senkal, Zeynep; Subasi, Nilufer; Karaer, Gulhan; Ergun, Serhat; Sari, Ibrahim; Sayar, Kemal
dc.date.accessioned2022-03-14T08:13:50Z
dc.date.available2022-03-14T08:13:50Z
dc.date.issued2016-09
dc.description.abstractObjective: Depression and anxiety are associated with both subdinical and clinical cardiovascular disease. Endothelial dysfunction, atherosclerosis, and inflammation are some of the underlying mechanisms. Pulse wave velocity (PWV) and augmentation index (Alx) are noninvasive markers for evaluation of arterial stiffness. The aim of this study was to examine the association between arterial stiffness parameters and depression/anxiety scores in depressive patients undergoing psychiatric treatment. Methods: The study population consisted of 30 patients with depression undergoing psychiatric treatment at least 4 weeks, and 25 age and gender matched healthy controls. Depression and anxiety were assessed by self-reported scales, including the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Measurements of arterial stiffness parameters were performed by using a Mobil-O-Graph arteriograph system, which detects signals from the brachial artery. Results: Baseline characteristics and clinical data were similar between the two groups. BDI and BAI scores were statistically significantly higher in patients with depression (p<0.001, p<0.01). PWV and Alx were statistically significantly higher in patients with depression compared to controls (6.40 +/- 1.31 m/s vs 5.51 +/- 0.41 m/s and 26.9 +/- 12.1 % vs 17.4 +/- 11.3 %, p=0.001, p=0.004, respectively). PWV and Alx positively, mildly and statistically significantly correlated with BDI and BAI scores. Conclusion: Arterial stiffness parameters were statistically significantly higher in depressive patients receiving antidepressant treatment. Moreover, arterial stiffness parameters statistically significantly correlated with BDI and BAI. Assessment of arterial stiffness parameters may be useful for early detection of cardiovascular deterioration in depressive patients undergoing antidepressant treatment.
dc.identifier.doi10.5455/bcp.20160325085828
dc.identifier.issn1017-7833
dc.identifier.urihttps://hdl.handle.net/11424/241155
dc.identifier.wosWOS:000385785800010
dc.language.isoeng
dc.publisherKURE ILETISIM GRUBU A S
dc.relation.ispartofKLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectarterial stiffness
dc.subjectpulse wave velocity
dc.subjectaugmentation index
dc.subjectdepression
dc.subjectanxiety
dc.subjectCORONARY-HEART-DISEASE
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectENDOTHELIAL FUNCTION
dc.subjectHYPERTENSIVE PATIENTS
dc.subjectMAJOR DEPRESSION
dc.subjectMETAANALYSIS
dc.subjectRISK
dc.subjectPARTICIPANTS
dc.subjectINVENTORY
dc.subjectPRESSURE
dc.titleSeverity of Depression and Anxiety Symptoms is Associated with Increased Arterial Stiffness in Depressive Disorder Patients Undergoing Psychiatric Treatment
dc.typearticle
dspace.entity.typePublication
local.avesis.id15094e22-196f-47c3-87da-41c4162623f9
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage293
oaire.citation.issue3
oaire.citation.startPage287
oaire.citation.titleKLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
oaire.citation.volume26
relation.isAuthorOfPublication26c97c3b-389c-4a43-9329-8693aa3c3333
relation.isAuthorOfPublication.latestForDiscovery26c97c3b-389c-4a43-9329-8693aa3c3333

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