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The choroid and lamina cribrosa is affected in patients with Parkinson's disease: enhanced depth imaging optical coherence tomography study

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dc.contributor.authorÇERMAN, EREN
dc.contributor.authorsEraslan, Muhsin; Cerman, Eren; Balci, Sevcan Yildiz; Celiker, Hande; Sahin, Ozlem; Temel, Ahmet; Suer, Devran; Elmaci, Nese Tuncer
dc.date.accessioned2022-03-14T08:14:16Z
dc.date.available2022-03-14T08:14:16Z
dc.date.issued2016-02
dc.description.abstractPurpose: To compare lamina cribrosa (LC) and choroidal thicknesses using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with Parkinson's disease (PD) and healthy controls. Methods: A total number of 44 eyes of 22 patients with PD and 50 eyes of 25 healthy subjects were utilized in this institutional cross-sectional study. After a complete ophthalmic examination, all eyes were imaged with OCT (RTVue-100 version 5.1 Fourier-domain optical coherence tomography; Optovue Inc., Fremont, CA, USA); LC and choroidal thickness were assessed. Results: The mean LC thicknesses were 209.4 +/- 40.2 mu m in patients with PD and 292.5 +/- 33.7 mu m in control subjects. There was a significant difference in the mean LC thickness between the groups (p < 0.0001). The choroidal thickness measurements of the PD group at the subfoveal region and 1.5 mm temporal and 1.5 mm nasal to the fovea were 228.1 +/- 44.3, 193.2 +/- 41.4 and 188.4 +/- 49.0 lm, respectively, whereas measurements for the controls were, respectively, 246.5 +/- 38.2, 227.3 +/- 34.7 and 216.7 +/- 51.4 lm. The choroid was significantly thinner in eyes of the PD group compared to that of the controls (p = 0.001, p < 0.001, and p = 0.006). There was no significant correlation between the disease severity and OCT parameters. The duration of the disease showed a statistically significant negative correlation with LC (rs[94] = -0.700, p < 0.001), and average subfoveal and temporal and nasal choroid thicknesses (rs[94] = -0.282, p = 0.006; rs[94] = -0.324, p = 0.001, rs[94] = -0.240, and p = 0.020, respectively). Conclusions: Regardless of the disease severity, PD may cause atrophy and volume loss in the lamina cribrosa, and choroid. An enhanced depth imaging technique may be used as an additional modality in the diagnosis and follow-up of patients with PD.
dc.identifier.doi10.1111/aos.12809
dc.identifier.eissn1755-3768
dc.identifier.issn1755-375X
dc.identifier.pubmed26268377
dc.identifier.urihttps://hdl.handle.net/11424/241221
dc.identifier.wosWOS:000368732300011
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofACTA OPHTHALMOLOGICA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchoroidal thickness
dc.subjectenhanced depth imaging
dc.subjectenhanced depth imaging
dc.subjectlamina cribrosa
dc.subjectoptical coherence tomography
dc.subjectParkinson's disease
dc.subjectretinal nerve fibre layer
dc.subjectRNFL
dc.subjectCENTRAL SEROUS CHORIORETINOPATHY
dc.subjectMILD COGNITIVE IMPAIRMENT
dc.subjectOCULAR PERFUSION-PRESSURE
dc.subjectALZHEIMERS-DISEASE
dc.subjectMACULAR DEGENERATION
dc.subjectNERVE HEAD
dc.subjectORTHOSTATIC HYPOTENSION
dc.subjectMULTIPLE-SCLEROSIS
dc.subjectRETINAL PATHOLOGY
dc.subjectDIURNAL-VARIATION
dc.titleThe choroid and lamina cribrosa is affected in patients with Parkinson's disease: enhanced depth imaging optical coherence tomography study
dc.typearticle
dspace.entity.typePublication
local.avesis.ida0690832-ed0a-4a92-9fa3-24b2d0611645
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ1
oaire.citation.endPageE75
oaire.citation.issue1
oaire.citation.startPageE68
oaire.citation.titleACTA OPHTHALMOLOGICA
oaire.citation.volume94
relation.isAuthorOfPublication94b7eabe-feca-456f-8edb-62cf4425293a
relation.isAuthorOfPublication.latestForDiscovery94b7eabe-feca-456f-8edb-62cf4425293a

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