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The protective effect of oxytocin on renal ischemia/reperfusion injury in rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsTugtepe, Halil; Sener, Goksel; Biyikli, Nese Karaaslan; Yuksel, Meral; Cetinel, Sule; Gedik, Nursal; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:32:40Z
dc.date.available2022-03-12T17:32:40Z
dc.date.issued2007
dc.description.abstractAim: Oxytocin was previously shown to have anti-inflammatory effects in different inflammation models. The major objective of the present study was to evaluate the protective role of oxytocin (OT) in protecting the kidney against ischemia/reperfusion (I/R) injury. Materials and methods: Male Wistar albino rats (250-300 g) were unilaterally nephrectornized, and subjected to 45 min of renal pedicle occlusion followed by 6 It of reperfusion. OT (1 mg/kg, ip) or vehicle was administered 15 min prior to ischemia and was repeated immediately before the reperfusion period. At the end of the reperfusion period, rats were decapitated and kidney samples were taken for histological examination or determination of malondialdehyde (MDA), an end product of lipid peroxidation; glutathione (GSH), a key antioxidant; and myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration. Creatinine and urea concentrations in blood were measured for the evaluation of renal function, while TNF-alpha and lactate dehydrogenase (LDH) levels were determined to evaluate generalized tissue damage. Formation of reactive oxygen species in renal tissue samples was monitored by chemiluminescence technique using luminol and lucigenin probes. Results: The results revealed that I/R injury increased (p < 0.01-0.001) serum urea, creatinine, TNF-alpha and LDH levels, as well as MDA, MPO and reactive oxygen radical levels in the renal tissue, while decreasing renal GSH content. However, alterations in these biochemical and histopathological indices due to l/R injury were attenuated by OT treatment (P < 0.05-0.001). Conclusions: Since OT administration improved renal function and microscopic damage, along with the alleviation of oxidant tissue responses, it appears that oxytocin protects renal tissue against I/R-induced oxidative damage. (c) 2006 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.regpep.2006.11.026
dc.identifier.eissn1873-1686
dc.identifier.issn0167-0115
dc.identifier.pubmed17261335
dc.identifier.urihttps://hdl.handle.net/11424/228653
dc.identifier.wosWOS:000246086400001
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofREGULATORY PEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoxytocin
dc.subjectischemia/reperfusion
dc.subjectkidney
dc.subjectlipid peroxidation
dc.subjectmyeloperoxidase
dc.subjectglutathione
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectNEUTROPHIL-DEPENDENT MECHANISM
dc.subjectATRIAL-NATRIURETIC-PEPTIDE
dc.subjectADHESION MOLECULES
dc.subjectFAILURE
dc.subjectRECEPTORS
dc.subjectKIDNEY
dc.subjectMYELOPEROXIDASE
dc.subjectINFLAMMATION
dc.titleThe protective effect of oxytocin on renal ischemia/reperfusion injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id665476e5-526f-4971-8c41-26122f568115
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage108
oaire.citation.issue3
oaire.citation.startPage101
oaire.citation.titleREGULATORY PEPTIDES
oaire.citation.volume140
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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