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Height, weight, IGF-I, IGFBP-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: Effect of methylphenidate treatment

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsBereket, A; Turan, S; Karaman, MG; Haklar, G; Ozbay, F; Yazgan, MY
dc.date.accessioned2022-03-12T17:19:27Z
dc.date.available2022-03-12T17:19:27Z
dc.date.issued2005
dc.description.abstractObjective: To investigate if there are any disease-related or methylphenidate-induced aberrations in growth parameters, growth hormone insulin-like growth factor (IGF)- I, IGFBP-3 axis and the thyroid function tests in children with attention deficit hyperactivity disorder (ADHD). Methods: Newly diagnosed and untreated prepubertal children with ADHD were longitudinally followed before and approximately every 4 months after methylphenidate treatment for up to 16 months. Height SDS, weight SDS, BMI SDS, serum GH, IGF-I, IGFBP-3, T-4, free T-4, T-3, and TSH were measured at each visit. Results: All of the examined parameters were within normal limits for age before treatment. Methylphenidate treatment did not significantly affect SDS of height, weight, BMI, IGF-I and IGFBP-3 in the long run. Serum T-4 and free T-4 levels showed modest reductions within normal limits in a time-dependent manner. Conclusions: Prepubertal children with ADHD had normal height, weight, BMI, serum IGF-I and IGFBP-3 and thyroid functions. Methylphenidate treatment had no sustained effects on growth parameters, IGF-I and IGFBP-3 during the follow-up period of this study. However, it caused a mild decrease in total and free T-4 which may warrant further monitoring. Copyright (C) 2005 S. Karger AG, Basel.
dc.identifier.doi10.1159/000084683
dc.identifier.eissn1663-2826
dc.identifier.issn0301-0163
dc.identifier.pubmed15795512
dc.identifier.urihttps://hdl.handle.net/11424/228108
dc.identifier.wosWOS:000229814600001
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofHORMONE RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectattention deficit hyperactivity disorder
dc.subjectgrowth in hyperactive children
dc.subjectIGF-I
dc.subjectIGFBP-3
dc.subjectthyroid
dc.subjectmethylphenidate
dc.subjectGROWTH DEFICITS
dc.subjectRESISTANCE
dc.subjectIMIPRAMINE
dc.subjectADHD
dc.titleHeight, weight, IGF-I, IGFBP-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: Effect of methylphenidate treatment
dc.typearticle
dspace.entity.typePublication
local.avesis.idb810f919-114c-44a4-a3c6-3659f90c2755
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage164
oaire.citation.issue4
oaire.citation.startPage159
oaire.citation.titleHORMONE RESEARCH
oaire.citation.volume63
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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