Publication:
Induced sputum as a method for detection of systemic sclerosis-related interstitial lung disease

Simple item page
dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsYilmaz, Neslihan; Abul, Yasin; Bicakcigil, Muge; Golabi, Pejman; Celikel, Cigdem; Karakurt, Sait; Yavuz, Sule
dc.date.accessioned2022-03-12T18:07:17Z
dc.date.available2022-03-12T18:07:17Z
dc.date.issued2012
dc.description.abstractInducted sputum (IS) is a non-invasive procedure that can be used for collection of airway secretions. The aim of our study is to evaluate the clinical usefulness of IS for detection of airway inflammation in systemic sclerosis (SSc). Bronchoalveolar lavage and IS were performed to 20 patients with SSc. Eighteen patients who were referred to pulmonary medicine for bronchoalveolar lavage due to other reasons were also recruited for cell counts comparisons. Spirometry, echocardiography and thorax CT (HRCT) imaging were also performed to all patients. Mean macrophage and lymphocyte counts were found to be increased in IS of SSc patients compared with that of control (58.4 +/- A 14.5% vs. 31.3 +/- A 16.3%, 30.2 +/- A 15.4% vs. 15.0 +/- A 11.5% P < 0.001), whereas mean neutrophil count was lower in the SSc patients (4.1 +/- A 4.5% vs. 17.2 +/- A 13.1%, P < 0.05). Significant correlations were noted between BAL and IS findings for macrophage (r = 0.55, P = 0.02) lymphocyte (r = 0.65, P < 0.01) and total cell counts (r = 0.45, P = 0.06). IS is an easy and reliable method for the detection of alveolitis and can be used for early detection of lung involvement in scleroderma.
dc.identifier.doi10.1007/s00296-011-1872-4
dc.identifier.eissn1437-160X
dc.identifier.issn0172-8172
dc.identifier.pubmed21448645
dc.identifier.urihttps://hdl.handle.net/11424/231001
dc.identifier.wosWOS:000305680700009
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofRHEUMATOLOGY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectScleroderma
dc.subjectInduced sputum
dc.subjectInterstitial lung disease
dc.subjectBRONCHOALVEOLAR LAVAGE
dc.subjectSARCOIDOSIS
dc.subjectMANAGEMENT
dc.subjectINDUCTION
dc.titleInduced sputum as a method for detection of systemic sclerosis-related interstitial lung disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id49a688bd-ec75-4b64-bae2-dda490fee960
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage1925
oaire.citation.issue7
oaire.citation.startPage1921
oaire.citation.titleRHEUMATOLOGY INTERNATIONAL
oaire.citation.volume32
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

Files

Collections

Research Outputs