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Studies on cis-DDP, [Pt(Dach)(MePhSO)CI]+ and [Pt(NH3)2(N-Py)CI]+ binding to fumarase

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1995

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Two platinum analogs which have suitable physical properties and show antineoplastic activities comparable or greater than that obtained with cis-DDP were synthesized: [cis-Pt A2 (Am) Cl] NO3 and [Pt (dach) (RR'SO) Cl] NO3 (A: ammonia, Am: pyridine, dach: transdiaminocyclohexane, RR'sO: methylphenylsulphoxide). Their interactions with fumarase were studied. The inhibition of fumarase activity by the platinum compounds was followed kinetically by a spectrophotometric method. These two platinum compounds generally inhibited fumarase less than cis-DDP at the concentrations and reaction media (phosphate buffer or NaCl-buffer) studied. © Freund Publishing House, Ltd. 1995

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cis-dichlorodiamineplatinum(II), cis-[Pt(NH3)2(pyridine)CI]NO3, fumarase, inhibition, [Pt(MePhSO)(diaminocyclohexane) CI] NO3

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https://hdl.handle.net/11424/246249

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