Publication: Studies on cis-DDP, [Pt(Dach)(MePhSO)CI]+ and [Pt(NH3)2(N-Py)CI]+ binding to fumarase
| dc.contributor.authors | Yalçin G. | |
| dc.date.accessioned | 2022-03-15T01:53:05Z | |
| dc.date.accessioned | 2026-01-11T19:18:53Z | |
| dc.date.available | 2022-03-15T01:53:05Z | |
| dc.date.issued | 1995 | |
| dc.description.abstract | Two platinum analogs which have suitable physical properties and show antineoplastic activities comparable or greater than that obtained with cis-DDP were synthesized: [cis-Pt A2 (Am) Cl] NO3 and [Pt (dach) (RR'SO) Cl] NO3 (A: ammonia, Am: pyridine, dach: transdiaminocyclohexane, RR'sO: methylphenylsulphoxide). Their interactions with fumarase were studied. The inhibition of fumarase activity by the platinum compounds was followed kinetically by a spectrophotometric method. These two platinum compounds generally inhibited fumarase less than cis-DDP at the concentrations and reaction media (phosphate buffer or NaCl-buffer) studied. © Freund Publishing House, Ltd. 1995 | |
| dc.identifier.doi | 10.1515/DMDI.1995.12.2.105 | |
| dc.identifier.issn | 7925077 | |
| dc.identifier.pubmed | 8591689 | |
| dc.identifier.uri | https://hdl.handle.net/11424/246249 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Drug Metabolism and Drug Interactions | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | cis-dichlorodiamineplatinum(II) | |
| dc.subject | cis-[Pt(NH3)2(pyridine)CI]NO3 | |
| dc.subject | fumarase | |
| dc.subject | inhibition | |
| dc.subject | [Pt(MePhSO)(diaminocyclohexane) CI] NO3 | |
| dc.title | Studies on cis-DDP, [Pt(Dach)(MePhSO)CI]+ and [Pt(NH3)2(N-Py)CI]+ binding to fumarase | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 116 | |
| oaire.citation.issue | 2 | |
| oaire.citation.startPage | 105 | |
| oaire.citation.title | Drug Metabolism and Drug Interactions | |
| oaire.citation.volume | 12 |