Publication:
-174 G/C polymorphism of interleukin 6 gene is not significantly different in Turkish professional short and long distance runners

Simple item page
dc.contributor.authorsArica, Secil; Solgun, Huscyin Avni; Dengi, Ayse Seda Demirel; Bakmaz, Enver; Akcays, Teoman; Kapici, Sezgin; Sercan, Canan; Ulucan, Korkut
dc.date.accessioned2022-03-14T10:16:11Z
dc.date.available2022-03-14T10:16:11Z
dc.date.issued2018-08-30
dc.description.abstractInterleukin-6 (IL-6) is a kind of multifunctional cytokine and involved in mediating muscle repair metabolism, and therefore athletic capacity. Muscular and circulating IL-6 levels increase in response to physical exercise. Responsible gene coding for IL-6 has a functional polymorphism in its promoter region, -174 G/C (rs1800795). We aimed to analyze the association of G allele and GG genotype in Turkish professional athletes and compare the allelic and genotypic difference between short distance and long distance runners. For this purpose, we enrolled 40 (24 short distance runners and 16 long distance runners) Turkish professional athletes to the study. Real time genotyping procedure was carried out to determine the -174 G/C polymorphism. G allele and GG genotype was more prevalent than the others in our cohort. We found no statistically significant difference between short and long distance runners in the terms of genotype (p-0.07). Our study suggests that-174 G/C polymorphism of IL-6 gene differs in athletes, G allele and GG genotype is higher than the other ones, at least in Turkish athletes. and therefore should be taken into consideration when determining genetic aspects of athletes. Further studies arc necessary to confirm our results and show the effect of the given polymorphism in sports science.
dc.identifier.doi10.14715/cmb/2018.64.11.15
dc.identifier.eissn1165-158X
dc.identifier.issn0145-5680
dc.identifier.pubmed30213294
dc.identifier.urihttps://hdl.handle.net/11424/244284
dc.identifier.wosWOS:000446024200002
dc.language.isoeng
dc.publisherC M B ASSOC
dc.relation.ispartofCELLULAR AND MOLECULAR BIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSport genetics
dc.subjectEndurance
dc.subjectAthlete
dc.subjectGenomics
dc.subjectIL6 GENE
dc.subjectPERFORMANCE
dc.subjectEXERCISE
dc.subjectMUSCLE
dc.title-174 G/C polymorphism of interleukin 6 gene is not significantly different in Turkish professional short and long distance runners
dc.typearticle
dspace.entity.typePublication
local.avesis.id18cf516c-8a71-472c-9aa3-98da54de3ece
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages3
local.journal.quartileQ4
oaire.citation.endPage87
oaire.citation.issue11
oaire.citation.startPage85
oaire.citation.titleCELLULAR AND MOLECULAR BIOLOGY
oaire.citation.volume64

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Arica et al. - 2018 - −174 GC polymorphism of interleukin 6 gene is n.pdf
Size:
334.16 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs