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Design and fabrication of electrospun polycaprolactone/chitosan scaffolds for ligament regeneration

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dc.contributor.authorİNAN, AHMET TALAT
dc.contributor.authorsSaatcioglu, Elif; Ulag, Songul; Sahin, Ali; Yilmaz, Betul Karademir; Ekren, Nazmi; Inan, Ahmet Talat; Palaci, Yuksel; Ustundag, Cem Bulent; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:55:53Z
dc.date.available2022-03-12T22:55:53Z
dc.date.issued2021
dc.description.abstractTendon and ligament impairments are among the most familiar injuries of the knee with acute or chronic pain conditions. The defects of anterior cruciate ligament (ACL) stay a known clinical problem. In the present study, the electrospinning method was used to fabricate 10wt.%PCL/(1, 3, 5)wt.%Chitosan (CS) appropriate and biocompatible scaffolds with a similar connective ligament geometry and structure. 10wt.%PCL/3wt.%CS demonstrated higher tensile strength value (0.58854 MPa) than other scaffolds in the tensile test. Moreover, 10wt.%PCL/3wt.%CS scaffolds had high mesenchymal stem cells (MSCs) viability value for all incubation periods. Swelling and degradation behaviours of the ligament-like scaffolds were examined in vitro for 15 days. Results reported that the highest swelling ratio was observed with CS addition for 10wt.%PCL/5wt.%CS scaffolds which value nearly reached to the 270% ratio. Scanning electron microscope proved the geometry of the scaffolds, which were suitable for ligament-like tissue. Attachment of MSCs on the scaffolds proved the network-like structure of the cells on the scaffolds.
dc.identifier.doi10.1016/j.eurpolymj.2021.110357
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/11424/236849
dc.identifier.wosWOS:000639291300011
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnterior cruciate ligament (ACL)
dc.subjectChitosan
dc.subjectPCL
dc.subjectLigament
dc.subjectScaffold
dc.titleDesign and fabrication of electrospun polycaprolactone/chitosan scaffolds for ligament regeneration
dc.typearticle
dspace.entity.typePublication
local.avesis.idf723041e-00b0-460f-afff-a2ba6fe21800
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber110357
local.journal.numberofpages7
oaire.citation.titleEUROPEAN POLYMER JOURNAL
oaire.citation.volume148
relation.isAuthorOfPublication523a8f6a-88ba-46c7-9bc5-8bbab957b2c5
relation.isAuthorOfPublication.latestForDiscovery523a8f6a-88ba-46c7-9bc5-8bbab957b2c5

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