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Clinical predictors of steroid resistance in childhood nephrotic syndrome

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dc.contributor.authorÇİÇEK DENİZ, NESLİHAN
dc.contributor.authorsCicek N., Yıldız N., Guven S., Kaya M., Gokce I., Alpay H.
dc.date.accessioned2023-12-27T06:29:17Z
dc.date.available2023-12-27T06:29:17Z
dc.date.issued2023-12-24
dc.description.abstractWe aimed to evaluate the clinical parameters, histopathological findings of nephrotic syndrome (NS) patients, and independent factors predicting steroid resistance in a single tertiary center. One hundred and sixty-two children (57 girls and 105 boys) with NS who were followed between 1998 and 2018 were analyzed in this retrospective cohort. The median (interquartile range; range) age and follow-up time were 4.9 (5.7; 0.1-16.8) and 5.5 (5.4; 0.1-20.3) years. A total of 82.7% of the patients were steroid-sensitive nephrotic syndrome (SSNS) and 17.3% were steroid-resistant nephrotic syndrome (SRNS). The median age at first presentation was lower in the SSNS group (P = .002). The most common histopathological findings were focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Hypertension and macroscopic and microscopic hematuria were higher in the SRNS group (P < .001). The age and microscopic hematuria were independent risk factors for steroid resistance (P = .019 and P = .002, respectively). Complement 3 (C3) was evaluated in 148 patients and found low in 7 patients who were subsequently diagnosed as membranoproliferative glomerulonephritis. There is still no better clinical predictor for steroid response than late age of onset and microscopic hematuria. Hypertension may also give a hint for potential steroid resistance.
dc.identifier.citationCicek N., Yıldız N., Guven S., Kaya M., Gokce I., Alpay H., "Clinical Predictors of Steroid Resistance in Childhood Nephrotic Syndrome.", Clinical pediatrics, 2023
dc.identifier.doi10.1177/00099228231219109
dc.identifier.issn0009-9228
dc.identifier.urihttps://hdl.handle.net/11424/296050
dc.language.isoeng
dc.relation.ispartofClinical pediatrics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleClinical predictors of steroid resistance in childhood nephrotic syndrome
dc.typearticle
dspace.entity.typePublication
local.avesis.idc68ebc3f-8e2e-49cd-9bfe-c7137ea95a12
local.indexed.atPUBMED
relation.isAuthorOfPublication00158ab2-6abe-4f34-9358-5808e1da7d68
relation.isAuthorOfPublication.latestForDiscovery00158ab2-6abe-4f34-9358-5808e1da7d68

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