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Differences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma

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dc.contributor.authorBOZKURTLAR, EMİNE
dc.contributor.authorsErcelep, Ozlem; Alan, Ozkan; Telli, Tugba A.; Tuylu, Tugba B.; Arikan, Rukiye; Demircan, Nazim Can; Simsek, Eda T.; Babacan, Nalan A.; Kaya, Serap; Dane, Faysal; Bozkurtlar, Emine; Ones, Tunc; Lacin, Tunc; Yumuk, Perran Fulden
dc.date.accessioned2022-03-12T22:40:27Z
dc.date.available2022-03-12T22:40:27Z
dc.date.issued2021
dc.description.abstractPurpose: Lung adenocarcinoma is histologically diverse but has distinct histologic growth patterns. There is no consensus on the clinical benefit of this histologic model. We aimed to evaluate the differences in the distribution of the preoperative primary tumor positron emission tomography (PET)/computed tomography (CT) standardized uptake values (SUVs) and survival in the lung adenocarcinoma subtypes. Methods: We retrospectively evaluated the data of 107 patients with resected lung adenocarcinoma who had preoperative PET/CT between 2005 and 2017 in a single center. Patients had lepidic, acinar, papillary, micropapillary, and solid histologic subtypes. We compared fluorodeoxyglucose SUVs and survival data of histologic subtypes. Results: The median age of the patients was 62 years (40-75), 76.4% were male, the median SUVmax was 9.4 (1-36.7), and the median follow-up time was 29 months (3-135 months). The median overall survival (OS) was 71 months and the median progression-free survival (PFS) was 33 months. SUVmax was significantly different in histologic subtypes: values for papillary, micropapillary, solid, acinar, and lepidic subtypes were 9.7, 8, 12, 9.1, and 3.9, respectively (p= 0.000). Solid predominant adenocarcinoma had significantly higher SUVmax than the other subtypes (p= 0.001). Lepidic predominant adenocarcinoma had significantly lower SUVmax than the other subtypes (p= 0.000). There was no significant difference in OS between histologic subtypes (p= 0.66), but PFS was significantly different between the groups (p= 0.017), and the solid subtype had a shorter PFS than the other histologic subtypes. Conclusion: Lung adenocarcinoma consists of a diverse group of diseases. Different SUVmax values are seen in different histologic subtypes of nonmetastatic lung adenocarcinoma. Solid predominant types have high SUVmax values while lepidic predominant types have lower SUVmax values. The solid subtype had a shorter PFS than the other histologic subtypes.
dc.identifier.doi10.1177/0300891620950475
dc.identifier.eissn2038-2529
dc.identifier.issn0300-8916
dc.identifier.pubmed32878562
dc.identifier.urihttps://hdl.handle.net/11424/235962
dc.identifier.wosWOS:000568093200001
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofTUMORI JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectlung adenocarcinoma
dc.subjectFDG
dc.subjectPET
dc.subjectSUVmax
dc.subjecthistologic subtypes
dc.subjectBRONCHIOLOALVEOLAR CARCINOMA
dc.subjectFDG UPTAKE
dc.subjectINTERNATIONAL-ASSOCIATION
dc.subjectCANCER
dc.subjectCLASSIFICATION
dc.subjectEXPRESSION
dc.subjectDIAMETER
dc.subjectFEATURES
dc.subjectGLUT-1
dc.subjectLESS
dc.titleDifferences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma
dc.typearticle
dspace.entity.typePublication
local.avesis.idd05e7656-1d84-4c3d-b511-46b775a293a4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber300891620950475
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage237
oaire.citation.issue3
oaire.citation.startPage231
oaire.citation.titleTUMORI JOURNAL
oaire.citation.volume107
relation.isAuthorOfPublication2343a71e-12cf-42ea-89ed-b222d121f733
relation.isAuthorOfPublication.latestForDiscovery2343a71e-12cf-42ea-89ed-b222d121f733

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