Publication: Peripheral T-Cell Lymphoma Coexisting with Autoimmune Hemolytic Anemia: Analysis of Clinical Features
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Date
2024-01-01
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Abstract
Autoimmune hemolytic anemia (AIHA) is characterized
by the production of antibodies targeting red blood cells
(RBCs) antigens. The diagnosis is based on the presence
of a hemolytic anemia with a positive direct antiglobulin
test (or Coombs test) and on the absence of any other
hereditary or acquired cause of hemolysis, although direct
antiglobulin test-negative cases are not quite uncommon
(5% of 308 cases of AIHA recently reported by the Gruppo
Italiano Malattie EMatologiche dell’Adulto [GIMEMA])
[1, 2]. AIHA can present in primary and secondary forms.
Secondary AIHA generally includes factors such as connective
tissue diseases, drugs, infections, and lymphomas [3].
Cases of AIHA accompanied by lymphoma are rare and are
typically presented in the literature as case reports. Roughly
one-fifth of AIHA patients have lymphoma, while 7–10%
of lymphoma patients have co-existing AIHA, indicating
a clinicopathological link between both diseases [4–6]. In
clinical settings, AIHA is commonly associated with indolent
B-cell lymphomas, whereas the combination of AIHA
with peripheral T-cell lymphoma (PTCL) is rarely observed
[7–11]. This study retrospectively analyzes the clinical data,
laboratory characteristics, treatment processes, and prognosis
of five patients with the coexistence of PTCL and AIHA
who were diagnosed within the last 10 years in our center.
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Keywords
Tıp, Dahili Tıp Bilimleri, İç Hastalıkları, Hematoloji, Sağlık Bilimleri, Medicine, Internal Medicine Sciences, Internal Diseases, Hematology, Health Sciences, Klinik Tıp (MED), Klinik Tıp, HEMATOLOJİ, Clinical Medicine (MED), CLINICAL MEDICINE, HEMATOLOGY
Citation
Candan O., Naghizada N., DEMİRTAŞ D., YANIK A. M., Salim S., Menguc M. U., Arikan F., YILMAZ A. F., ATAGÜNDÜZ I., TUĞLULAR A. T., et al., "Peripheral T-Cell Lymphoma Coexisting with Autoimmune Hemolytic Anemia: Analysis of Clinical Features", Indian Journal of Hematology and Blood Transfusion, 2024