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Urinary NGF, TGF-beta 1, TIMP-2 and Bladder Wall Thickness Predict Neurourological Findings in Children with Myelodysplasia

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dc.contributor.authorŞEKERCİ, ÇAĞRI AKIN
dc.contributor.authorsSekerci, Cagri Akin; Isbilen, Banu; Isman, Ferruh; Akbal, Cem; Simsek, Ferruh; Tarcan, Tufan
dc.date.accessioned2022-03-13T12:45:35Z
dc.date.available2022-03-13T12:45:35Z
dc.date.issued2014
dc.description.abstractPurpose: Dimercapto-succinic acid scintigraphy and urodynamic studies are gold standards to evaluate renal scarring and neurogenic bladder dysfunction, respectively. We sought to establish the value of bladder wall thickness together with urine NGF, TGF-beta 1 and TIMP-2 to predict the urodynamic profile and upper urinary tract damage in children with myelodysplasia. Materials and Methods: A total of 80 children with myelodysplasia underwent urodynamic investigation, bladder wall thickness measurement and dimercaptosuccinic acid scintigraphy with basic neurourological evaluation. Two study and 2 control groups were created according to presence or absence of renal scarring on dimercapto-succinic acid scan (study and control groups 1) and according to detrusor leak point pressure greater or less than 40 cm H2O (study and control groups 2). Urine samples were analyzed with ELISA. Results: The study population consisted of 44 girls and 36 boys with a median +/- SD age of 7.2 +/- 3.6 years (range 2 to 17). Study and control groups 1 consisted of 35 and 45 children with abnormal and normal dimercapto-succinic acid scan findings, respectively. Study and control groups 2 included 30 and 50 children with detrusor leak point pressure greater and less than 40 cm H2O, respectively. Bladder wall thickness and urinary levels of TGF-beta 1, NGF and TIMP-2 were significantly increased in both study groups compared to controls. Conclusions: Urine markers and bladder wall thickness measurement may predict urinary tract impairment in children with myelodysplasia. Such markers may differentiate at risk patients with either renal scarring or high detrusor leak point pressure, and decrease the need for urodynamics and renal scintigraphy.
dc.identifier.doi10.1016/j.juro.2013.08.025
dc.identifier.eissn1527-3792
dc.identifier.issn0022-5347
dc.identifier.pubmed23973519
dc.identifier.urihttps://hdl.handle.net/11424/237808
dc.identifier.wosWOS:000329191700074
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF UROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnerve growth factor
dc.subjectneural tube defects
dc.subjecttissue inhibitor of metalloproteinase-2
dc.subjecttransforming growth factor beta1
dc.subjecturinary bladder
dc.subjectneurogenic
dc.subjectNERVE GROWTH-FACTOR
dc.subjectOVERACTIVE BLADDER
dc.subjectTRANSFORMING GROWTH-FACTOR-BETA-1
dc.subjectMATRIX METALLOPROTEINASES
dc.subjectULTRASOUND ASSESSMENT
dc.subjectJUNCTION OBSTRUCTION
dc.subjectDETRUSOR THICKNESS
dc.subjectSMOOTH-MUSCLE
dc.subjectINHIBITORS
dc.titleUrinary NGF, TGF-beta 1, TIMP-2 and Bladder Wall Thickness Predict Neurourological Findings in Children with Myelodysplasia
dc.typearticle
dspace.entity.typePublication
local.avesis.ideaa3d217-ed51-4ec7-ac30-7cf3559a7d07
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage205
oaire.citation.issue1
oaire.citation.startPage199
oaire.citation.titleJOURNAL OF UROLOGY
oaire.citation.volume191
relation.isAuthorOfPublication1e489bdb-418e-4500-a522-6c0babb604b9
relation.isAuthorOfPublication.latestForDiscovery1e489bdb-418e-4500-a522-6c0babb604b9

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