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Intraarterial thrombolysis with r-tPA for treatment of anterior circulation acute ischemic stroke - Technical and clinical results

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dc.contributor.authorBALTACIOĞLU, FEYYAZ
dc.contributor.authorsBaltacioglu, F; Afsar, N; Ekinci, G; Tuncer-Elmaci, N; Cimsit, NC; Aktan, S; Erzen, C
dc.date.accessioned2022-03-14T11:06:07Z
dc.date.available2022-03-14T11:06:07Z
dc.date.issued2003-09
dc.description.abstractTo investigate factors effecting the safety and recanalization efficacy of local intraarterial (IA) recombinant tissue plasminogen activator (r-tPA) delivery in patients with acute ischemic stroke. Eleven patients with anterior circulation acute ischemic stroke were treated. The neurological status of the patients were graded with the Glasgow Coma Scale (GCS) and National Institute of Health Stroke Scale (NIHSS). All patients underwent a computed tomography (CT) examination at admission. In addition four patients had diffusion-weighted and one patient had a perfusion magnetic resonance (MR) examinations. Patients were treated within six hours from stroke onset. Immediate, six hours, and 24 hours follow-up CT examinations were performed in order to evaluate the haemorrhagic complications and the extent of the ischemic area. The Rankin Scale (RS) was used as an outcome measure. Two of the 11 patients had carotid T occlusion (CTO), nine had middle cerebral artery (MCA) main trunk occlusion. Four patients had symptomatic haemorrhage with a large haematoma rupturing into the ventricles and subarachnoid space. Of these, three patients died within 24 hours. The remaining seven patients had asymptomatic haematomas that were smaller compared to symptomatic ones, and showed regression in size and density on follow-up CTs. At third month five patients had a good outcome and three patients had a poor outcome. In acute ischemic stroke, local IA thrombolysis is a feasible treatment when you select the right patient. Haemorrhage rate does not seem to exceed that occuring in the natural history of the disease and in other treatment modalities.
dc.identifier.doi10.1177/159101990300900306
dc.identifier.eissn2385-2011
dc.identifier.issn1591-0199
dc.identifier.pubmed20591253
dc.identifier.urihttps://hdl.handle.net/11424/245882
dc.identifier.wosWOS:000188659000006
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofINTERVENTIONAL NEURORADIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectischemic stroke
dc.subjectintraarterial thrombolysis
dc.subjectr-tPA
dc.subjectTISSUE-PLASMINOGEN-ACTIVATOR
dc.subjectMIDDLE CEREBRAL-ARTERY
dc.subjectCOOPERATIVE ACUTE STROKE
dc.subjectCAROTID TERRITORY STROKE
dc.subjectHEMORRHAGIC TRANSFORMATION
dc.subjectFIBRINOLYTIC THERAPY
dc.subjectEARLY CT
dc.subjectOCCLUSION
dc.subjectPROGNOSIS
dc.subjectANGIOGRAPHY
dc.titleIntraarterial thrombolysis with r-tPA for treatment of anterior circulation acute ischemic stroke - Technical and clinical results
dc.typearticle
dspace.entity.typePublication
local.avesis.id5d7aaec8-22b2-473f-a2e7-dde835aaded3
local.import.packageSS16
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage282
oaire.citation.issue3
oaire.citation.startPage273
oaire.citation.titleINTERVENTIONAL NEURORADIOLOGY
oaire.citation.volume9
relation.isAuthorOfPublication14b6381a-4f6e-4ff9-92f6-842a481bc163
relation.isAuthorOfPublication.latestForDiscovery14b6381a-4f6e-4ff9-92f6-842a481bc163

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