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Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsSener, Goksel; Sehirli, Ozer; Tozan, Ayfer; Velioglu-Ovunc, Ayliz; Gedik, Nursal; Omurtag, Gulden Z.
dc.date.accessioned2022-03-12T17:32:45Z
dc.date.available2022-03-12T17:32:45Z
dc.date.issued2007
dc.description.abstractMercury(II) is a highly toxic metal which induces oxidative stress in the body. In this study we aimed to investigate the possible protective effect of Ginkgo biloba (EGb), an antioxidant agent, against experimental mercury toxicity in rat model. Following a single dose of 5 mg/kg mercuric chloride (HgCl2; Hg group) either saline or EGb (150 mg/kg) was administered for 5 days. After decapitation of the rats trunk blood was obtained and the tissue samples from the brain, lung, liver, and kidney were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen contents. Formation of reactive oxygen species in the tissue samples was monitored by chemiluminescence (CL) technique. BUN, creatinin, ALT, and AST levels and tumor necrosis factor-alpha (TNF-alpha) and lactate dehydrogenase (LDH) activity were assayed in serum samples. The results revealed that HgCl2 induced oxidative damage Caused significant decrease in GSH level, significant increase in MDA level, MPO activity and collagen content of the tissues. Treatment of rats with EGb significantly increased the GSH level and decreased the MDA level, MPO activity, and collagen contents. Similarly, serum ALT, AST and BUN levels, as well as LDH and TNF-alpha, were elevated in the Hg group as compared to control group. On the other hand, EGb treatment reversed all these biochemical indices. Our results implicate that mercury-induced oxidative damage in brain, lung, liver, and kidney tissues protected by G. biloba extract, with its antioxidant effects. (c) 2006 Published by Elsevier Ltd.
dc.identifier.doi10.1016/j.fct.2006.07.024
dc.identifier.issn0278-6915
dc.identifier.pubmed17267089
dc.identifier.urihttps://hdl.handle.net/11424/228681
dc.identifier.wosWOS:000245758000003
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmercury chloride
dc.subjectGinkgo biloba
dc.subjectlipid peroxidation
dc.subjectTNF-alpha
dc.subjectLIPID-PEROXIDATION
dc.subjectNITRIC-OXIDE
dc.subjectEGB 761
dc.subjectREACTIVE OXYGEN
dc.subjectIN-VIVO
dc.subjectMERCURY
dc.subjectSTRESS
dc.subjectMELATONIN
dc.subjectKIDNEY
dc.subjectMYELOPEROXIDASE
dc.titleGinkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idbef558c6-4408-4e2c-ab70-0b1f2db24a49
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage550
oaire.citation.issue4
oaire.citation.startPage543
oaire.citation.titleFOOD AND CHEMICAL TOXICOLOGY
oaire.citation.volume45
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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