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Protective effects of resveratrol against acetaminophen-induced toxicity in mice

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsSener, Goksel; Toklu, Hale Z.; Sehirli, A. Ozer; Velioglu-Ogunc, Ayliz; Cetinel, Sule; Gedik, Nursal
dc.date.accessioned2022-03-12T17:19:42Z
dc.date.available2022-03-12T17:19:42Z
dc.date.issued2006
dc.description.abstractThis investigation elucidates the role of free radicals in acetaminophen (AA)-induced toxicity and the possible protection by resveratrol (RVT). BALB-c mice were injected with a single dose of 900 mg/kg AA to induce toxicity, while RVT administred in a dose of 30 mg/kg i.p. following AA. Mice were sacrificed 4 h after AA injection to determine serum ALT, AST and tumor necrosis factor-alpha (TNF-alpha) levels in blood, and glutathione (GSH), malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver tissues. Formation of reactive oxygen species in hepatic tissue samples was monitored by using chemiluminescence (CL) technique with luminol and lucigenin probe. ALT, AST levels and TNF-alpha were increased significantly after AA treatment, and reduced with RVT. AA caused a significant decrease in GSH levels while MDA levels and MPO activity were increased in liver tissues. On the other hand when RVT administered following AA, depletion of GSH and accumulation of MDA and neutrophil infiltration were reversed back to control. Furthermore increased luminol and lucigenin CL levels in the AA group reduced by RVT treatment. Our results implicate that AA causes oxidative damage in hepatic tissues and RVT, by its potent antioxidant effects protects the liver tissue. These data suggest that RVT may be of therapeutic use in preventing hepatic oxidative injury due to AA toxicity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.hepres.2006.02.005
dc.identifier.eissn1872-034X
dc.identifier.issn1386-6346
dc.identifier.pubmed16595188
dc.identifier.urihttps://hdl.handle.net/11424/228145
dc.identifier.wosWOS:000237619600010
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofHEPATOLOGY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacetaminophen
dc.subjectresveratrol
dc.subjecthepatic
dc.subjectglutathione
dc.subjectTNF-alpha
dc.subjectmyeloperoxidase
dc.subjectRED WINE
dc.subjectOXIDATIVE STRESS
dc.subjectREACTIVE OXYGEN
dc.subjectFREE-RADICALS
dc.subjectPROTEIN
dc.subjectINJURY
dc.subjectHEPATOTOXICITY
dc.subjectGLUTATHIONE
dc.subjectMECHANISMS
dc.subjectMELATONIN
dc.titleProtective effects of resveratrol against acetaminophen-induced toxicity in mice
dc.typearticle
dspace.entity.typePublication
local.avesis.id8d4021e2-27eb-4252-9290-cbf8a3114be2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage68
oaire.citation.issue1
oaire.citation.startPage62
oaire.citation.titleHEPATOLOGY RESEARCH
oaire.citation.volume35
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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