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A novel multi-target strategy for Alzheimer?s disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers

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dc.contributor.authorBÖCEKÇİ, VEYSEL GÖKHAN
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorERTAŞ, BÜŞRA
dc.contributor.authorsTopal F., ERTAŞ B., Guler E., Gurbuz F., Ozcan G. S., Aydemir O., BÖCEKÇİ V. G., DURUKSU G., ŞAHİN ÇAM C., YAZIR Y., et al.
dc.date.accessioned2023-07-07T07:15:38Z
dc.date.available2023-07-07T07:15:38Z
dc.date.issued2022-07-01
dc.description.abstractDrug delivery systems that not only show efficacy through multiple therapeutic pathways but also facilitate patient drug use and exhibit a high bioavailability profile represent a promising strategy in the treatment of Alzheimer???s disease (AD). Here, donepezil (DO)/memantine (MM)/curcumin (CUR)-loaded electrospun nanofibers (NFs) were produced for the treatment of AD. DSC, XRD, and FT-IR studies demonstrated the complete incorporation of the drug into PVA/PVP NFs. The disintegration profile was improved by loading the drugs in PVA/PVP with fast wetting (less than 1 s), the start of disintegration (21 s), and dispersion in 110 s. The desired properties for sublingual application were achieved with the dissolution of NFs in 240 s. The cell viability in DO/ MM/CUR-loaded NFs was similar to the control group after 48 h in the cell culture. DO/MM/CUR-loaded NFs enhanced the expressions of BDNF (13.5-fold), TUBB3 (8.9-fold), Neurog2 (5.6-fold), NeuroD1 (5.8-fold), Nestin (166-fold), and GFAP (115-fold). DO/MM/CUR-loaded NFs and powder of these drugs contained in these fibers were daily administered sublingually to intracerebroventricular-streptozotocin (icv-STZ) treated rats. DO/MM/ CUR-loaded NFs treatment improved the short-term memory damage and enhanced memory, learning ability, and spatial exploration talent. Results indicated that the levels of A??, Tau protein, APP, GSK-3??, AChE, and TNF-?? were significantly decreased, and BDNF was increased by DO/MM/CUR-loaded NFs treatment compared to the AD group. In the histopathological analysis of the hippocampus and cortex, neuritic plaques and neurofibrillary nodes were not observed in the rats treated with DO/MM/CUR-loaded NFs. Taken together, the sublingual route delivery of DO/MM/CUR-loaded NFs supports potential clinical applications for AD.
dc.identifier.citationTopal F., ERTAŞ B., Guler E., Gurbuz F., Ozcan G. S., Aydemir O., BÖCEKÇİ V. G., DURUKSU G., ŞAHİN ÇAM C., YAZIR Y., et al., "A novel multi-target strategy for Alzheimer?s disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers", BIOMATERIALS ADVANCES, cilt.138, 2022
dc.identifier.doi10.1016/j.bioadv.2022.212870
dc.identifier.issn2772-9508
dc.identifier.urihttps://hdl.handle.net/11424/290897
dc.identifier.volume138
dc.language.isoeng
dc.relation.ispartofBIOMATERIALS ADVANCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer ?s disease
dc.subjectMemantine
dc.subjectDonepezil
dc.subjectCurcumin
dc.subjectElectrospun nanofiber
dc.subjectMEMORY DEFICITS
dc.subjectIN-VITRO
dc.subjectSUSTAINED-RELEASE
dc.subjectDRUG-RELEASE
dc.subjectSTEM-CELLS
dc.subjectSTREPTOZOTOCIN
dc.subjectDONEPEZIL
dc.subjectDEMENTIA
dc.subjectBRAIN
dc.subjectACID
dc.titleA novel multi-target strategy for Alzheimer?s disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers
dc.typearticle
dspace.entity.typePublication
local.avesis.ide653bdbe-9648-4f86-9d1a-af211c4c473f
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication864e7cb0-b39f-48bb-a546-ee65ffc807b2
relation.isAuthorOfPublication.latestForDiscovery8c13c515-8fc5-4df0-b755-2be6b01fedb1

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