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Withdrawal of inhaled steroids in children with non-cystic fibrosis bronchiectasis

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsGuran, T.; Ersu, R.; Karadag, B.; Karakoc, F.; Demirel, G. Y.; Hekim, N.; Dagli, E.
dc.date.accessioned2022-03-12T17:35:00Z
dc.date.available2022-03-12T17:35:00Z
dc.date.issued2008
dc.description.abstractTo study the effects of inhaled steroid withdrawal on bronchial hyperreactivity, sputum inflammatory markers and neutrophilic apoptosis in children with non-cystic fibrosis (non-CF) bronchiectasis. To evaluate the role of inhaled steroids in the treatment of children with non-CF bronchiectasis with specific emphasis on the bronchial hyperreactivity and neutrophilic apoptosis. Twenty-seven children with steady-state non-CF bronchiectasis were evaluated primarily with metacholine challenge tests and apoptotic neutrophil ratios in induced sputum and secondarily with symptom scores, pulmonary function tests and tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) levels and neutrophil ratios in induced sputum before and after 12-week withdrawal of inhaled steroids. There were 16 girls and 11 boys. Median (interquartile range) age was 11.4 (9.5-13.6) years, follow-up duration was 3.5 (2-6.5) years. Symptom scores (4 vs. 3; P = 0.27), oxygen saturation (95% vs. 97%; P = 0.06), pulmonary function tests (FEV1: 82% predicted vs. 83% predicted; P = 0.73), sputum neutrophil ratios (29.9% vs. 46.8%; P = 0.20), TNF-alpha (58 pg/mL vs. 44.5 pg/mL; P = 0.55) and IL-8 (2.7 ng/mL vs. 2.4 ng/mL; P = 0.82) levels in induced sputum were similar before and after 12-week withdrawal of inhaled steroids. However, the number of patients with bronchial hyperreactivity increased (37% vs. 63% of patients; P = 0.016) and neutrophilic apoptosis in induced sputum decreased (42.8% vs. 20.2%; P = 0.03) after withdrawal. In this study, 12 week-withdrawal of inhaled steroid treatment resulted in a significant increase in bronchial hyperreactivity and decrease in neutrophil apoptosis, but no change in sputum inflammatory markers in children with non-CF bronchiectasis was observed.
dc.identifier.doi10.1111/j.1365-2710.2008.00951.x
dc.identifier.eissn1365-2710
dc.identifier.issn0269-4727
dc.identifier.pubmed19138237
dc.identifier.urihttps://hdl.handle.net/11424/229103
dc.identifier.wosWOS:000260823600004
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapoptosis
dc.subjectbronchial hyperreactivity
dc.subjectbronchiectasis
dc.subjectchildren
dc.subjectinterleukin-8
dc.subjectinduced sputum
dc.subjecttumour necrosis factor-alpha
dc.subjectAIRWAY RESPONSIVENESS
dc.subjectINDUCED SPUTUM
dc.subjectLUNG-FUNCTION
dc.subjectBRONCHIAL HYPERREACTIVITY
dc.subjectFLUTICASONE PROPIONATE
dc.subjectINFLAMMATORY INDEXES
dc.subjectNEUTROPHIL APOPTOSIS
dc.subjectASTHMA
dc.subjectMETHACHOLINE
dc.subjectHYPERRESPONSIVENESS
dc.titleWithdrawal of inhaled steroids in children with non-cystic fibrosis bronchiectasis
dc.typearticle
dspace.entity.typePublication
local.avesis.id4d9ac33f-0643-4a38-aca8-2dd8cf42a16e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage611
oaire.citation.issue6
oaire.citation.startPage603
oaire.citation.titleJOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
oaire.citation.volume33
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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