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Peripheral nervous system assessment in acromegaly patients under somatostatin analogue therapy

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dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsAlibas, H.; Yavuz, D. Gogas; Koytak, P. Kahraman; Uygur, M.; Tanridag, T.; Uluc, K.
dc.date.accessioned2022-03-12T20:30:37Z
dc.date.available2022-03-12T20:30:37Z
dc.date.issued2017
dc.description.abstractPurpose Acromegaly is known to affect peripheral nervous system (PNS) causing carpal tunnel syndrome (CTS) and polyneuropathy. The frequency of these disorders and the evaluation methods vary among studies. In the present study, we aimed to examine PNS of acromegaly patients under somatostatin analogue (SSA) therapy. Methods Forty-eight acromegaly patients (26 F/22 M, 45.58 +/- 11.6 years) under SSA treatment and 44 healthy controls (25 F/19 M, 47.46 +/- 8.7 years) were assessed by symptom questionnaires, neurologic examination and electrophysiological studies. Results 87.5 % of the acromegaly patients had at least one abnormal finding regarding PNS. With the incorporation of palm-wrist median nerve conduction velocity method, we detected CTS in 50 % of patients. Polyneuropathy was less frequent (29.2 %). Both conditions were independent from the coexisting diabetes mellitus (p = 0.22 for CTS, p = 0.71 for polyneuropathy). Polyneuropathy but not CTS was more common among biochemically uncontrolled acromegaly patients rather than those under control (p = 0.03; p = 0.68, respectively). Conculsion Our findings emphasize the high prevalence of peripheral nervous system involvement in acromegaly patients under SSA therapy and importance of neurological evaluation of these patients. Early diagnosis and treatment of the disease may reduce the PNS involvement.
dc.identifier.doi10.1007/s40618-016-0522-9
dc.identifier.issn1720-8386
dc.identifier.pubmed27484912
dc.identifier.urihttps://hdl.handle.net/11424/234193
dc.identifier.wosWOS:000391430700005
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcromegaly
dc.subjectPeripheral nervous system
dc.subjectCarpal tunnel syndrome
dc.subjectPolyneuropathy
dc.subjectCARPAL-TUNNEL-SYNDROME
dc.subjectMANAGEMENT
dc.subjectNEUROPATHY
dc.subjectCONDUCTION
dc.subjectULTRASOUND
dc.subjectPAIN
dc.titlePeripheral nervous system assessment in acromegaly patients under somatostatin analogue therapy
dc.typearticle
dspace.entity.typePublication
local.avesis.id13613e0b-5aee-4160-8a27-330f75a5de61
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage40
oaire.citation.issue1
oaire.citation.startPage33
oaire.citation.titleJOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
oaire.citation.volume40
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

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