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Successful treatment of refractory graft-versus-host disease with ruxolitinib in a child after autologous stem cell transplantation

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dc.contributor.authorTRUE, ÖMER
dc.contributor.authorTOKUÇ, AYŞE GÜLNUR
dc.contributor.authorKOÇ, AHMET
dc.contributor.authorEKER, NURŞAH
dc.contributor.authorsEker N., Tas B. T., Doğru Ö., Senay E., Tokuç A. G., Koç A.
dc.date.accessioned2023-06-19T07:52:45Z
dc.date.available2023-06-19T07:52:45Z
dc.date.issued2022-06-01
dc.description.abstractAutologous hematopoietic stem cell transplantation (AHSCT) is an increasingly used curative treatment for some solid tumors in children. Instead of allogeneic transplantation, the risk of developing graft-versus-host disease (GvHD) is much lower after AHSCT. Although the clinical findings of auto-GVHD are mild and self-limited in most cases, rare cases may be severe and need intensive immunosuppressive treatment. Here, we present a case who underwent autologous HSCT due to relapsed neuroblastoma, developed steroid-refractory GvHD after AHSCT, and achieved remission using ruxolitinib. A 12 years old female patient was diagnosed with relapsed neuroblastoma. After metaiodobenzylguanidine treatment, AHSCT was performed, and the status of the disease was a very good partial response at the time of transplantation. Our patient was diagnosed with severe and steroid-refractory GvHD with skin involvement after AHSCT. We used ruxolitinib with extracorporeal photopheresis because of the essential side effects of the other drugs and got a very good response. Over the following five months, there was no recurrence of GvHD. She was in complete remission of neuroblastoma after two years of AHSCT. It is crucial to keep in mind that GvHD may develop after AHSCT. Ruxolitinib is an effective treatment for GvHD also after AHSCT. Further studies and case reports are needed to understand the disease\"s pathogenesis and regulate appropriate treatment.
dc.identifier.citationEker N., Tas B. T., Doğru Ö., Senay E., Tokuç A. G., Koç A., "Successful Treatment of Refractory Graft-Versus-Host Disease with Ruxolitinib in a Child after Autologous Stem Cell Transplantation", JOURNAL OF PEDIATRIC RESEARCH, cilt.9, sa.2, ss.197-200, 2022
dc.identifier.doi10.4274/jpr.galenos.2022.69335
dc.identifier.endpage200
dc.identifier.issn2147-9445
dc.identifier.issue2
dc.identifier.startpage197
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/977e4924-de07-4648-8872-a6dc070b8a2f/file
dc.identifier.urihttps://hdl.handle.net/11424/290407
dc.identifier.volume9
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PEDIATRIC RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPEDIATRICS
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPediatri
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectPediatrics
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectAutologous stem cell transplantation
dc.subjectchildren
dc.subjectgraft versus host disease
dc.subjectruxolitinib
dc.subjectsteroid-resistant
dc.subjectAutologous stem cell transplantation
dc.subjectchildren
dc.subjectgraft versus host disease
dc.subjectruxolitinib
dc.subjectsteroid-resistant
dc.titleSuccessful treatment of refractory graft-versus-host disease with ruxolitinib in a child after autologous stem cell transplantation
dc.typearticle
dspace.entity.typePublication
local.avesis.id977e4924-de07-4648-8872-a6dc070b8a2f
local.indexed.atWOS
local.indexed.atTRDIZIN
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