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Stereological and electrophysiological evaluation of autonomic involvement in amyotrophic lateral sclerosis

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dc.contributor.authorAKDENİZ, ESRA
dc.contributor.authorİŞAK, BARIŞ
dc.contributor.authorsOzturk R., Karlsson P., Hu X., AKDENİZ E., Surucu S., İŞAK B.
dc.date.accessioned2022-12-28T07:17:16Z
dc.date.available2022-12-28T07:17:16Z
dc.date.issued2022-11-01
dc.description.abstract© 2022 Elsevier Masson SASObjective: Previous studies have identified autonomic dysfunction in amyotrophic lateral sclerosis (ALS) using mostly neurophysiological techniques. In this study, stereological evaluation of autonomic fibers and sweat glands has been performed to identify structural evidence of autonomic denervation in patients with ALS. Methods: In this study, 29 ALS patients were compared to 29 controls using COMPASS-31 questionnaire, sympathetic skin response (SSR), and heart rate variability (HRV) at rest. From the same cohorts, 20 ALS patients and 15 controls were further evaluated using staining of autonomic nerve fibers and sweat glands in skin biopsies. SSR and resting HRV were repeated in the ALS patient cohort one year later. Results: COMPASS-31 total score, gastrointestinal- and urinary-sub scores were higher in ALS patients than controls (P = 0.004, P = 0.005, and P = 0.049, respectively). In the ALS patient cohort, SSR amplitudes in hands and feet were lower than in controls (P0.05). While there was no change in nerve fibers innervating sweat glands, their density was lower in ALS patients than controls, and semi-quantitative analysis also showed structural damage (P = 0.02 and P = 0.001, respectively). SSR and resting HRV of ALS patients remained stable during the one-year follow-up period (P>0.05). Discussion: Supporting abnormal neurophysiological tests, stereological analysis revealed direct evidence of autonomic denervation in ALS patients. However, the degenerative process in autonomic nerve fibers is relatively slow, compared to the rate of motor neuron degeneration in this condition.
dc.identifier.citationOzturk R., Karlsson P., Hu X., AKDENİZ E., Surucu S., İŞAK B., "Stereological and electrophysiological evaluation of autonomic involvement in amyotrophic lateral sclerosis", Neurophysiologie Clinique, cilt.52, sa.6, ss.446-458, 2022
dc.identifier.doi10.1016/j.neucli.2022.08.003
dc.identifier.endpage458
dc.identifier.issn0987-7053
dc.identifier.issue6
dc.identifier.startpage446
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142779372&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284404
dc.identifier.volume52
dc.language.isoeng
dc.relation.ispartofNeurophysiologie Clinique
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectFizyoloji
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectHuman Physiology
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectBiyoloji ve Biyokimya
dc.subjectFİZYOLOJİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectPHYSIOLOGY
dc.subjectCLINICAL NEUROLOGY
dc.subjectNöroloji (klinik)
dc.subjectFizyoloji (tıbbi)
dc.subjectNeurology (clinical)
dc.subjectPhysiology (medical)
dc.subjectAmyotrophic lateral sclerosis
dc.subjectAutonomic nervous system
dc.subjectHeart rate variability
dc.subjectMotor neuron
dc.subjectSkin biopsy
dc.subjectSympathetic skin response
dc.titleStereological and electrophysiological evaluation of autonomic involvement in amyotrophic lateral sclerosis
dc.typearticle
dspace.entity.typePublication
local.avesis.idcbb59b42-3302-4ec9-82fc-d7e0a40d469a
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication247544af-fbb8-4147-a94d-b693a76513de
relation.isAuthorOfPublication3978eebd-304b-4af3-930c-2db9759c860d
relation.isAuthorOfPublication.latestForDiscovery247544af-fbb8-4147-a94d-b693a76513de

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