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Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature

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2015

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SPRINGER JAPAN KK

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Abstract

The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.

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t(9;22), Myelodysplastic syndrome, BCR-JAK2, Fusion gene, JAK2 rearrangement, CHRONIC EOSINOPHILIC LEUKEMIA, ACUTE LYMPHOBLASTIC-LEUKEMIA, CHRONIC MYELOID-LEUKEMIA, JAK2, TRANSLOCATION, PATIENT, GENE, RUXOLITINIB, REARRANGEMENTS, DISORDERS

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https://hdl.handle.net/11424/220198

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