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Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature

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dc.contributor.authorTOPTAŞ, TAYFUR
dc.contributor.authorsKantarcioglu, Bulent; Kaygusuz-Atagunduz, Isik; Uzay, Ant; Toptas, Tayfur; Tuglular, Tulin Firatli; Bayik, Mahmut
dc.date.accessioned2022-03-10T15:25:18Z
dc.date.accessioned2026-01-11T17:23:53Z
dc.date.available2022-03-10T15:25:18Z
dc.date.issued2015
dc.description.abstractThe human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.
dc.identifier.doi10.1007/s12185-015-1792-2
dc.identifier.eissn1865-3774
dc.identifier.issn0925-5710
dc.identifier.pubmed25833723
dc.identifier.urihttps://hdl.handle.net/11424/220198
dc.identifier.wosWOS:000360939400019
dc.language.isoeng
dc.publisherSPRINGER JAPAN KK
dc.relation.ispartofINTERNATIONAL JOURNAL OF HEMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectt(9;22)
dc.subjectMyelodysplastic syndrome
dc.subjectBCR-JAK2
dc.subjectFusion gene
dc.subjectJAK2 rearrangement
dc.subjectCHRONIC EOSINOPHILIC LEUKEMIA
dc.subjectACUTE LYMPHOBLASTIC-LEUKEMIA
dc.subjectCHRONIC MYELOID-LEUKEMIA
dc.subjectJAK2
dc.subjectTRANSLOCATION
dc.subjectPATIENT
dc.subjectGENE
dc.subjectRUXOLITINIB
dc.subjectREARRANGEMENTS
dc.subjectDISORDERS
dc.titleMyelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature
dc.typereview
dspace.entity.typePublication
oaire.citation.endPage387
oaire.citation.issue3
oaire.citation.startPage383
oaire.citation.titleINTERNATIONAL JOURNAL OF HEMATOLOGY
oaire.citation.volume102

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