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Melatonin improves hyperglycemia induced damages in rat brain

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsGurel-Gokmen, Begum; Ipekci, Hazal; Oktay, Sehkar; Alev, Burcin; Ustundag, Unsal Veli; Ak, Esin; Akakin, Dilek; Sener, Goksel; Emekli-Alturfan, Ebru; Yarat, Aysen; Tunali-Akbay, Tugba
dc.date.accessioned2022-03-12T22:24:26Z
dc.date.available2022-03-12T22:24:26Z
dc.date.issued2018
dc.description.abstractBackground Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the development of diabetic complications. Melatonin is the hormone that interacts with insulin in diabetes. Therefore, in this study, the effects of melatonin treatment with or without insulin were examined in diabetic rat brain. Methods Results Rats were divided into five groups as control, diabetes, diabetes + insulin, diabetes + melatonin, and diabetes + melatonin + insulin. Experimental diabetes was induced by streptozotocin (60 mg/kg, i.p.). Twelve weeks after diabetes induction, rats were decapitated. Malondialdehyde, glutathione, sialic acid and nitric oxide levels, superoxide dismutase, catalase, glutathione-S-transferase, myeloperoxidase, and tissue factor activities were determined in brain tissue. Melatonin alone showed its antioxidant effect by increasing brain glutathione level, superoxide dismutase, catalase, and glutathione-S-transferase activities and decreasing malondialdehyde level in experimental diabetes. Although insulin did not have a significant effect on glutathione and glutathione-S-transferase, its effects on lipid peroxidation, superoxide dismutase, and catalase were similar to melatonin; insulin also decreased myolopeoxidase activity and increased tissue factor activity. Combined melatonin and insulin treatment mimicked the effects of insulin. Conclusion Addition of melatonin to the insulin treatment did not change the effects of insulin, but the detailed role of melatonin alone in the treatment of diabetes merits further experimental and clinical investigation.
dc.identifier.doi10.1002/dmrr.3060
dc.identifier.eissn1520-7560
dc.identifier.issn1520-7552
dc.identifier.pubmed30098300
dc.identifier.urihttps://hdl.handle.net/11424/234758
dc.identifier.wosWOS:000449703400011
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofDIABETES-METABOLISM RESEARCH AND REVIEWS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbrain
dc.subjectdiabetes
dc.subjectinsulin
dc.subjectmelatonin
dc.subjectoxidative stress
dc.subjectADVANCED GLYCATION ENDPRODUCTS
dc.subjectOXIDATIVE STRESS
dc.subjectTISSUE FACTOR
dc.subjectDIABETES-MELLITUS
dc.subjectCORTICAL-NEURONS
dc.subjectSTREPTOZOTOCIN
dc.subjectINSULIN
dc.subjectGLUCOSE
dc.subjectBLOOD
dc.subjectPLASMA
dc.titleMelatonin improves hyperglycemia induced damages in rat brain
dc.typearticle
dspace.entity.typePublication
local.avesis.idb067e4da-4b0b-4592-95ec-c90eb75280d6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere3060
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.issue8
oaire.citation.titleDIABETES-METABOLISM RESEARCH AND REVIEWS
oaire.citation.volume34
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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