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Topographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsGulcebi, Medine Idrizoglu; Ketenci, Sema; Linke, Rudiger; Hacioglu, Husniye; Yanali, Hasan; Veliskova, Jana; Moshe, Solomon L.; Onata, Filiz; Cavdar, Safiye
dc.date.accessioned2022-03-12T18:07:21Z
dc.date.available2022-03-12T18:07:21Z
dc.date.issued2012
dc.description.abstractThe substantia nigra pars reticulata (SNR) is the ventral subdivision of the substantia nigra and contains mostly GABAergic neurons. The present study explores whether the SNR relates to all dorsal thalamic nuclei equally or just to a particular group of nuclei, such as first or higher-order nuclei. Injections of biotinylated dextran amine (BDA) were made into the SNR of 10 male adult rats. The distribution of anterogradely labelled axon terminals in the thalamic nuclei was documented. The projections of the SNR to the thalamic nuclei were exclusively to some motor higher-order, but not to first-order thalamic relays. There were bilateral projections to the ventromedial (VM), parafascicular (PF), centromedian (CM) and paracentral (PC) nuclei and unilateral projections to the centrolateral (CL), mediodorsal (MD) and thalamic reticular nucleus (Rt). Labelled axon terminals in the thalamic nuclei ranged from numerous to sparse in VM, PF, CM, CL, PC, MD and Rt. Further, injections into the SNR along its rostral-caudal axis showed specific topographical connections with the thalamic nuclei. The rostral SNR injections showed labelled axon terminals of VM, PF, CL, PC, CM, MD and Rt. Caudal SNR injections showed labelling of VM, PF, PC, CM and MD. All injections showed labelled axons and terminals in the zona incerta. The nigrothalamic GABAergic neurons can be regarded as an important system for the regulation of motor activities. The SNR is in a position to influence large areas of the neocortex by modulating some of the motor higher-order thalamic nuclei directly or indirectly via Rt. (C) 2011 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.brainresbull.2011.11.005
dc.identifier.eissn1873-2747
dc.identifier.issn0361-9230
dc.identifier.pubmed22108631
dc.identifier.urihttps://hdl.handle.net/11424/231008
dc.identifier.wosWOS:000301548300023
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBRAIN RESEARCH BULLETIN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThalamus
dc.subjectSubstantia nigra pars reticulata
dc.subjectHigher-order
dc.subjectAnterograde tracing
dc.subjectBASAL GANGLIA
dc.subjectCORTICOTHALAMIC PROJECTIONS
dc.subjectDEVELOPMENTAL REGULATION
dc.subjectLATERAL GENICULATE
dc.subjectPREFRONTAL CORTEX
dc.subjectNEURONS
dc.subjectORGANIZATION
dc.subjectINNERVATION
dc.subject1ST-ORDER
dc.subjectINPUT
dc.titleTopographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat
dc.typearticle
dspace.entity.typePublication
local.avesis.id5c8cd054-f3d1-4309-b1c2-384b48bfc3e6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage318
oaire.citation.issue2-3
oaire.citation.startPage312
oaire.citation.titleBRAIN RESEARCH BULLETIN
oaire.citation.volume87
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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