Publication:
The ameliorative effects of melatonin on acetic acid-induced gastric ulcer in rats via its modulatory effects on gut microbiota

Simple item page
dc.contributor.authorYILDIRIM, ALPER
dc.contributor.authorsTamer, Sevil Arabaci; Yildirim, Alper; Cevik, Ozge; Aksu, Burak; Yuksel, Meral; Dertsiz, Ekin Kuntsal; Sirvanci, Serap; Yegen, Berrak C.
dc.date.accessioned2022-03-12T22:56:46Z
dc.date.available2022-03-12T22:56:46Z
dc.date.issued2021
dc.description.abstractPurpose: The aim of this study was of observe the possible protective effects of melatonin pretreatment on oxidative damage and microbiota alteration due to gastric ulcer in rats. Materials and Methods: Wistar-albino rats were given (n=32) melatonin (4 mg/kg/day), antibiotic mixture (AB; 1g/L ampicillin + 1g/L neomycin + 1g/L metronidazole), melatonin+AB in drinking water for 12 days or tap water for 15 days (control group; n=8). Subsequently, ulcer was induced. All treatments were continued for three days. Gastric tissues were obtained for biochemical and histopathological examinations, and fecal samples from the rectum were stored for bacteriological measurements. Results: MPO and MDA levels were increased in untreated ulcer groups compared to the control group. In addition, the levels of luminol-lucigenin chemiluminescence (CL) and 8-OHdG and TNF-alpha and IL-8 protein expressions were also increased, while TNF-alpha, IL-8, MDA, 8-OHdG, luminol and lucigenin CL levels were significantly decreased in the melatonin-treated ulcer groups. However, melatonin+AB pretreatment increased antioxidant GSH levels and anti-inflammatory IL-10 levels, and suppressed caspase-3 activity and reduced MPO back to control level. Conclusion: We anticipate that melatonin treatment, which is an effective antioxidant and radical scavenger, can accelerate ulcer healing along with antibiotics and increase the variety of bacteria impaired by antibiotics in the colon.
dc.identifier.doi10.17826/cumj.779854
dc.identifier.eissn2602-3040
dc.identifier.issn2602-3032
dc.identifier.urihttps://hdl.handle.net/11424/236967
dc.identifier.wosWOS:000632797000021
dc.language.isotur
dc.publisherCUKUROVA UNIV, FAC MEDICINE
dc.relation.ispartofCUKUROVA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectStomach ulcer
dc.subjectacetic acid
dc.subjectmelatonin
dc.titleThe ameliorative effects of melatonin on acetic acid-induced gastric ulcer in rats via its modulatory effects on gut microbiota
dc.typearticle
dspace.entity.typePublication
local.avesis.id71718d1f-a1b8-40c2-9a3e-81bc2cc40323
local.import.packageSS17
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages15
oaire.citation.endPage200
oaire.citation.issue1
oaire.citation.startPage186
oaire.citation.titleCUKUROVA MEDICAL JOURNAL
oaire.citation.volume46
relation.isAuthorOfPublication1840e6a0-5ec8-42b9-bca3-4e891749ac77
relation.isAuthorOfPublication.latestForDiscovery1840e6a0-5ec8-42b9-bca3-4e891749ac77

Files

Collections

Research Outputs