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Chemical composition of endemic Stachys subnuda Montbret & Aucher ex Benth. essential oil and its anti-inflammatory and antioxidant activities

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsSen, Ali; Kurkcuoglu, Mine; Bitis, Leyla; Dogan, Ahmet; Baser, Kemal Husnu Can
dc.date.accessioned2022-03-12T22:38:29Z
dc.date.available2022-03-12T22:38:29Z
dc.date.issued2019
dc.description.abstractThe essential oil of aerial parts of Stachys subnuda Montbret & Aucher ex Benth (S. subnuda) was analyzed by gas chromatography (GC) and GC/mass spectrometry (MS). Anti-inflammatory activity was evaluated by lipoxygenase inhibition assay. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid (ABTS) assays. Sixty-two constituents, comprising 97.1% of the total essential oil composition, were identified. Phytol (25.2%), beta-caryophyllene (11.2%), germacrene D (6.9%), and hexadecanoic acid (6.9%) were the major compounds of aerial part essential oils of S. subnuda. The essential oil showed significant radical scavenging activity with 50% inhibition (IC50) values of 0.124 and 0.204 mg/mL for ABTS and DPPH radicals, respectively. The essential oil exhibited moderate anti-inflammatory activity with an IC50 value of 0.419 mg/mL. The results indicated that S. subnuda essential oil had good anti-inflammatory and antioxidant activity. Also, this is first study on chemical composition, anti-inflammatory and antioxidant activity of S. subnuda essential oil.
dc.identifier.doi10.1080/10412905.2019.1567399
dc.identifier.eissn2163-8152
dc.identifier.issn1041-2905
dc.identifier.urihttps://hdl.handle.net/11424/235644
dc.identifier.wosWOS:000463498100001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofJOURNAL OF ESSENTIAL OIL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectStachys subnuda
dc.subjectessential oil
dc.subjectanti-inflammatory activity
dc.subjectantioxidant activity
dc.subjectVOLATILE CONSTITUENTS
dc.subjectBETA-CARYOPHYLLENE
dc.subjectPHYTOCHEMICAL ANALYSIS
dc.subjectBIOLOGICAL-ACTIVITIES
dc.subjectANTICANCER ACTIVITY
dc.subjectDIFFERENT REGIONS
dc.subjectCENTRAL APENNINES
dc.subjectRECH. FIL.
dc.subjectL.
dc.subjectLAMIACEAE
dc.titleChemical composition of endemic Stachys subnuda Montbret & Aucher ex Benth. essential oil and its anti-inflammatory and antioxidant activities
dc.typearticle
dspace.entity.typePublication
local.avesis.ida686084e-d715-4e9e-bd47-3269b4f71a14
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
local.journal.quartileQ3
oaire.citation.endPage334
oaire.citation.issue4
oaire.citation.startPage326
oaire.citation.titleJOURNAL OF ESSENTIAL OIL RESEARCH
oaire.citation.volume31
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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