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Ethanol extract of Cotinus coggygria leaves accelerates wound healing process in diabetic rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsAksoy, Halil; Sen, Ali; Sancar, Mesut; Sekerler, Turgut; Akakin, Dilek; Bitis, Leyla; Uras, Fikriye; Kultur, Sukran; Izzettin, Fikret Vehbi
dc.date.accessioned2022-03-14T08:15:42Z
dc.date.available2022-03-14T08:15:42Z
dc.date.issued2016-11
dc.description.abstractContext:Cotinus coggygria Scop. (Anacardiaceae) leaves that were used as wound healing in traditional Balkan and Anatolian folk medicine, could be potentially effective in treating diabetic wounds.Objective: This study investigates biochemical and histological effects of ethanol extract of C. coggygria (CCE) on excision wound model in diabetic rats.Materials and methods: This study was conducted on diabetic Wistar albino rats, which were injected by a single dose (50mg/kg i.p.) streptozotocin. Afterward an excision wound model was created in all animals; diabetic control rats were applied topically simple ointment and diabetic treatment rats were applied topically 5% (w/w) ointment with CC, once a day during the experimental period. Malondialdehyde, glutathione and hydroxyproline levels in wound tissues were investigated at the end of 3rd, 7th, and 14th days. Histopathological examination was also performed.Results: Hydroxyproline content was significantly increased in the CCE treated group versus control after the 3rd and 7th days (15.33 versus 11.83; 19.67 versus 15.67mg/g, p<0.05; respectively). A statistically significant elevation in glutathione at the end of 3rd, 7th, and 14th days (5.13 versus 1.58, p<0.05; 4.72 versus 1.88, p<0.05; 3.83 versus 1.88mol/g, p<0.05, respectively) and a statistically significant decrease in malondialdehyde level at the end of 7th day (4.49 versus 1.48nmol/g, p<0.05) were determined in the treated group versus control group. These results were also supported by histological analyses.Discussion and conclusion: These findings indicate that CCE accelerated the cutaneous wound healing process in diabetic wounds, in confirmation of its traditional use.
dc.identifier.doi10.1080/13880209.2016.1181660
dc.identifier.eissn1744-5116
dc.identifier.issn1388-0209
dc.identifier.pubmed27180800
dc.identifier.urihttps://hdl.handle.net/11424/241332
dc.identifier.wosWOS:000386041900045
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPHARMACEUTICAL BIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnacardiaceae
dc.subjectdiabetes
dc.subjectexcision wound
dc.subjecthydroxyproline
dc.subjectINJURY
dc.subjectTURKEY
dc.subjectSCOP.
dc.titleEthanol extract of Cotinus coggygria leaves accelerates wound healing process in diabetic rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ida8d82c26-5945-46de-99a5-8542db9cb6e8
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ2
oaire.citation.endPage2736
oaire.citation.issue11
oaire.citation.startPage2732
oaire.citation.titlePHARMACEUTICAL BIOLOGY
oaire.citation.volume54
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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