Publication: Effect of non-surgical periodontal treatmenton salivary IL-13 levels in periodontitis with andwithout type 2 diabetes
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Date
2022-06-10
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Abstract
Background & Aim: Interleukin (IL)-13 is an anti-inflammatory and
fibrogenic cytokine activated by T helper 2 cells. It has been shown
that IL-13 inhibits pro-inflammatory cytokine synthesis and
osteoclastogenesis. The aim of the study was to determine the effect
of non-surgical periodontal treatment (NSPT) on salivary IL-13 levels
in periodontitis patients with and without type 2 diabetes
mellitus (T2DM).
Methods: A total of 48 subjects, 12 systemically and periodontally
healthy (H), 12 periodontitis with well controlled T2DM, 12 periodontitis with poorly controlled T2DM and 12 systemically healthy periodontitis, were recruited for the study. All periodontitis patients
belonged to either Stage III or IV periodontitis. At baseline, all clinical
parameters including plaque index, gingival index, bleeding on probing,
probing depth and clinical attachment loss were recorded, and the
saliva samples were collected from all subjects, at 3 months following
the NSPT only from periodontitis groups. Salivary IL-13 levels were
analysed by enzyme-linked immunosorbent assay. This study was
supported by the grant from Marmara University Scientific Research
Projects Coordination Unit #SAG-A-080519-0172.
Results: All clinical parameters were higher in all periodontitis groups
than the healthy subjects at baseline (p < 0.05) and improved 3 months
after NSPT in all periodontitis groups (p < 0.05). At baseline, salivary
IL-13 levels were lower in all periodontitis groups compared to H
group (p < 0.05) but were similar among 3 periodontitis groups
(p > 0.05). At 3 months following NSPT IL-13 levels were increased in
all 3 periodontitis groups compared to baseline (p < 0.05).
Conclusions: This study has revealed that low levels of salivary IL-13
are associated with periodontitis not T2DM. IL-13 may be used as a
biomarker for both the diagnosis and treatment of periodontitis.
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Citation
YILDIRIM H. S., KALKAN Y., İYİGÜN S., DOĞAN B., \"Effect of non-surgical periodontal treatmenton salivary IL-13 levels in periodontitis with andwithout type 2 diabetes\", Europerio 10, Amsterdam, Hollanda, 15 Haziran 2022, cilt.49