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Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension

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dc.contributor.authorÇİNÇİN, AHMET ALTUĞ
dc.contributor.authorsSunbul, Murat; Gerin, Fethullah; Durmus, Erdal; Kivrak, Tarik; Sari, Ibrahim; Tigen, Kursat; Cincin, Altug
dc.date.accessioned2022-03-13T12:44:32Z
dc.date.available2022-03-13T12:44:32Z
dc.date.issued2014
dc.description.abstractBackground: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are associated with worse outcome in various diseases. Non-dipping blood pressure pattern is associated with higher cardiovascular mortality. The aim of this study was to explore the association between NLR and PLR in patients with dipper versus non-dipper hypertension. Methods: The study included 166 patients with hypertension. Eighty-three patients (40 male, mean age: 49.1 +/- 10.5 years) had dipper hypertension, while 83 patients (41 male, mean age: 52.3 +/- 12.7 years) had non-dipper hypertension. Results: Baseline demographic characteristics were similar in both groups. Patients with non-dipper hypertension had significantly higher NLR compared to dipper hypertension (2.3 +/- 0.9 versus 1.8 +/- 0.5, p < 0.001). Patients with non-dipper hypertension had significantly higher PLR compared to dipper hypertension (117.7 +/- 35.2 versus 100.9 +/- 30.5, p = 0.001). In univariate analysis, hyperlipidemia, smoking, presence of diabetes, PLR more than 107 and NLR more than 1.89 were among predictors of dipper and non-dipper status. In logistic regression analyses, only hyperlipidemia (odds ratio: 2.96, CI: 1.22-7.13) and PLR more than 107 (odds ratio: 2.62, Cl: 1.13-6.06) were independent predictors of dipper and non-dipper status. A PLR of 107 or higher predicted non-dipper status with a sensitivity of 66.3% and specificity of 68.7%. Conclusion: We demonstrated that patients with non-dipper hypertension had significantly higher NLR and PLR compared to dipper hypertension, which has not been reported previously. Moreover PLR more than 107 but not NLR was independent predictor of non-dipper status.
dc.identifier.doi10.3109/10641963.2013.804547
dc.identifier.eissn1525-6006
dc.identifier.issn1064-1963
dc.identifier.pubmed23786430
dc.identifier.urihttps://hdl.handle.net/11424/237566
dc.identifier.wosWOS:000336993300005
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HYPERTENSION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeutrophil to lymphocyte ratio
dc.subjectplatelet to lymphocyte ratio
dc.subjectdipper
dc.subjectnon-dipper
dc.subjecthypertension
dc.subjectBLOOD-PRESSURE
dc.subjectDYSFUNCTION
dc.subjectMORTALITY
dc.subjectRISK
dc.subjectATHEROSCLEROSIS
dc.subjectINFLAMMATION
dc.subjectASSOCIATION
dc.subjectPREDICTOR
dc.subjectOUTCOMES
dc.titleNeutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension
dc.typearticle
dspace.entity.typePublication
local.avesis.id16556798-c51f-4253-964e-af0106395635
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage221
oaire.citation.issue4
oaire.citation.startPage217
oaire.citation.titleCLINICAL AND EXPERIMENTAL HYPERTENSION
oaire.citation.volume36
relation.isAuthorOfPublication54255a29-54c0-43de-8bc5-39d805d1296a
relation.isAuthorOfPublication.latestForDiscovery54255a29-54c0-43de-8bc5-39d805d1296a

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