Publication:
Recurrent gastrointestinal bleeding in a patient with Eisenmenger syndrome using bosentan

Simple item page
dc.contributor.authorSARI, İBRAHİM
dc.contributor.authorsSari I., Cam H., Sait Dag M., Durmus E., Kivrak T., Tigen K., Davutoglu V.
dc.date.accessioned2022-03-15T02:10:01Z
dc.date.available2022-03-15T02:10:01Z
dc.date.issued2013
dc.description.abstractEisenmenger syndrome is associated with irreversible increase in pulmonary vascular resistance causing reduced survival. Bosentan, a non-selective endothelin receptor antagonist is the commonly used specific pulmonary arterial hypertension drug in Eisenmenger syndrome. In this paper, we present a case of recurrent gastrointestinal bleeding in a 23-year-old female with Eisenmenger syndrome who was only under bosentan treatment, which has not been reported previously. Most common adverse effect of bosentan is elevation in the liver enzymes however, bleeding complication is very rare. On the contrary, it was proposed that bosentan might be a potential protector against hyperacidity and mucosal erosion that occur as a consequence of stress. Although the mechanistic relationship of bleeding tendency and role of Eisenmenger syndrome concomitant with bosentan treatment is far from conclusive statement for now, this association warrants and should draw attention of clinicians and researches in this field. © 2013 Bentham Science Publishers.
dc.identifier.doi10.2174/1574886319999990001
dc.identifier.issn15748847
dc.identifier.pubmed24102362
dc.identifier.urihttps://hdl.handle.net/11424/247382
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Clinical Pharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBosentan
dc.subjectCongenital heart disease
dc.subjectEisenmenger
dc.subjectGastrointestinal bleeding
dc.subjectPulmonary hypertension
dc.titleRecurrent gastrointestinal bleeding in a patient with Eisenmenger syndrome using bosentan
dc.typearticle
dspace.entity.typePublication
local.avesis.ide00db9cc-7725-4010-bb4d-be191cd255a7
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
local.indexed.atPUBMED
oaire.citation.endPage283
oaire.citation.issue4
oaire.citation.startPage282
oaire.citation.titleCurrent Clinical Pharmacology
oaire.citation.volume8
relation.isAuthorOfPublication26c97c3b-389c-4a43-9329-8693aa3c3333
relation.isAuthorOfPublication.latestForDiscovery26c97c3b-389c-4a43-9329-8693aa3c3333

Files

Collections

Research Outputs