Publication:
Dermatologic Findings in Renal Transplant Recipients: Possible Effects of Immunosuppression Regimen and p53 Mutations

Simple item page
dc.contributor.authorTURAN, KADİR
dc.contributor.authorsSerdar, Z. A.; Eren, P. A.; Canbakan, M.; Turan, K.; Tellioglu, G.; Gulle, S.; Ozgezer, T.; Kara, M.; Berber, I.; Titiz, M. I.
dc.date.accessioned2022-03-12T17:48:16Z
dc.date.available2022-03-12T17:48:16Z
dc.date.issued2010
dc.description.abstractObjective. To analyze the dermatologic lesions and possible effects of immunosuppression treatment and p53 gene mutations on dermatologic findings in renal transplant recipients. Materials and Methods. The study included 163 renal transplant recipients. After dermatologic examination, cultures, and histopathologic and genetic analyses were performed. A single-strand conformation polymorphism technique was used to analyze p53 gene mutations. Patients were categorized into 3 groups according to time since the transplantation procedure. Results were analyzed using the chi(2) test, using a software program (SPSS version 13.0; SPSS, Inc, Chicago, Illinois). Results. Mean (SD) age of the 163 transplant recipients (65 women and 98 men) was 40 (11) years, and posttransplantation follow-up was 65 (55) months. The most frequently observed drug-related lesion was hypertrichosis, in 46 of 150 patients. Of 115 lesions, the most commonly observed were verruca vulgaris (n = 34) from viruses, and pityriasis versicolor (n = 21) from superficial fungal infections. Of the total group, 20 patients (12.2%) were mutation carriers. Compared with the entire cohort, the group with premalignant lesions demonstrated more p53 mutations (11% vs 50%; P = .004). Patients given cyclosporine therapy exhibited more premalignant or malignant cutaneous lesions compared with patients who received other agents (P = .03). Conclusion. Patients carrying p53 mutations developed a malignant lesion in the late posttransplantation period, which suggests the importance of prediction of risk.
dc.identifier.doi10.1016/j.transproceed.2010.05.165
dc.identifier.issn0041-1345
dc.identifier.pubmed20832539
dc.identifier.urihttps://hdl.handle.net/11424/229927
dc.identifier.wosWOS:000281942200023
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofTRANSPLANTATION PROCEEDINGS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSKIN DISEASES
dc.subjectCUTANEOUS MANIFESTATIONS
dc.subjectFOLLOW-UP
dc.subjectCANCER
dc.subjectPOSTTRANSPLANT
dc.titleDermatologic Findings in Renal Transplant Recipients: Possible Effects of Immunosuppression Regimen and p53 Mutations
dc.typearticle
dspace.entity.typePublication
local.avesis.idf96e7cfe-aba0-425c-a90a-128572732a5c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages4
oaire.citation.endPage2541
oaire.citation.issue7
oaire.citation.startPage2538
oaire.citation.titleTRANSPLANTATION PROCEEDINGS
oaire.citation.volume42
relation.isAuthorOfPublication9cc23fc2-5031-46cd-91a0-a2e13ab788d4
relation.isAuthorOfPublication.latestForDiscovery9cc23fc2-5031-46cd-91a0-a2e13ab788d4

Files

Collections

Research Outputs