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Neuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats: TROD-GROG 005

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsAtasoy B. M.
dc.date.accessioned2024-09-02T12:09:16Z
dc.date.available2024-09-02T12:09:16Z
dc.date.issued2024-12-01
dc.description.abstractAim: To investigate the potential radioprotective effects of Myrtus communis on brain tissue. Methods: Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately after (R + MC) irradiation for four days. Irradiation was applied 10 Gy in a single fraction. All rats were sacrificed on the fourth day of irradiation. Malondialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), and tissue factor activities (TFa) were determined for biochemical analysis. Hematoxylin&Eosin staining was done for histopathological analyses, and electrophoretic analyses were performed. Results: NO, MDA, and MPO levels were higher in all irradiated groups compared with the C group. MC administration decreased NO, MDA, and MPO levels in R + preMC and R + MC groups. MC administration increased GSH levels. TFa activity decreased in R groups but did not change with MC administration compared to the C group. Radiation-induced brain tissue injury decreased, and morphologically normal neurons were observed in both MC-added groups. Conclusion: Myrtus communis has a potential neuroprotective effect on brain tissue, attributed to its antioxidative, anti-inflammatory, and anti-lipid peroxidative properties.
dc.identifier.citationAtasoy B. M., "Neuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats: TROD-GROG 005", JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCIES, cilt.17, sa.4, ss.1-10, 2024
dc.identifier.doi10.1016/j.jrras.2024.101082
dc.identifier.endpage10
dc.identifier.issn1687-8507
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/519b4355-e352-48e0-88f5-574aa3627ee2/file
dc.identifier.urihttps://hdl.handle.net/11424/297591
dc.identifier.volume17
dc.language.isoeng
dc.relation.ispartofJOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCIES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectIonizing radiation
dc.subjectMyrtus communis
dc.subjectNeuroprotection
dc.subjectRadioprotection
dc.subjectRats
dc.titleNeuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats: TROD-GROG 005
dc.typearticle
dspace.entity.typePublication
local.avesis.id519b4355-e352-48e0-88f5-574aa3627ee2
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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